Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in oral lichen planus patients with or without microcytosis

IF 3.4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences Pub Date : 2025-05-22 DOI:10.1016/j.jds.2025.05.009

Yi-Pang Lee , Ying-Tai Jin , Julia Yu-Fong Chang , Yi-Ping Wang , Andy Sun , Chun-Pin Chiang

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引用次数: 0

Abstract

Background/purpose

Microcytosis is defined as having mean corpuscular volume (MCV) < 80 fL. This study evaluated whether 78 oral lichen planus (OLP) patients with microcytosis (microcytosis/OLP patients) and 510 OLP patients without microcytosis (non-microcytosis/OLP patients) had higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 588 healthy control subjects.

Materials and methods

Complete blood count and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 78 microcytosis/OLP patients, 510 non-microcytosis/OLP patients, and 588 healthy control subjects were measured and compared.

Results

We found that 71.8 %, 46.2 %, 10.3 %, 0.0 %, 18.0 %, and 20.5 % of 78 microcytosis/OLP patients and 18.0 %, 12.4 %, 10.2 %, 1.4 %, 21.6 %, and 24.1 % of 510 non-microcytosis/OLP patients had blood hemoglobin, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Both 78 microcytosis/OLP patients and 510 non-microcytosis/OLP patients had significantly higher frequencies of blood hemoglobin, serum iron and vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 588 healthy control subjects (all P-values <0.001). Moreover, 78 microcytosis/OLP patients had significantly higher frequencies of blood hemoglobin and serum iron deficiencies than 510 non-microcytosis/OLP patients.

Conclusion

We conclude that our 78 microcytosis/OLP patients and 510 non-microcytosis/OLP patients have significantly higher frequencies of anemia, serum iron and vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 588 healthy control subjects. Moreover, 78 microcytosis/OLP patients also have significantly higher frequencies of blood hemoglobin and serum iron deficiencies than 510 non-microcytosis/OLP patients.

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伴有或不伴有小细胞增多的口腔扁平苔藓患者的贫血、血液病缺乏、高同型半胱氨酸血症和胃壁细胞抗体阳性

背景/目的微细胞增多症被定义为具有平均红细胞体积（MCV）；本研究评估了78例伴有小细胞增多的口腔扁平苔藓（OLP）患者（microcytosis/OLP患者）和510例无小细胞增多的口腔扁平苔藓（OLP）患者（non-microcytosis/OLP患者）是否比588名健康对照者有更高的贫血、血液病缺乏、高同型半胱氨酸血症和血清胃壁细胞抗体（GPCA）阳性的频率。材料与方法测定78例小细胞增多/OLP患者、510例非小细胞增多/OLP患者和588例健康对照者的全血细胞计数和血清铁、维生素B12、叶酸、同型半胱氨酸和GPCA水平。结果78例小细胞增多/OLP患者中有71.8%、46.2%、10.3%、0.0%、18.0%、20.5%，510例非小细胞增多/OLP患者中分别有18.0%、12.4%、10.2%、1.4%、21.6%、24.1%存在血红蛋白、血清铁、维生素B12和叶酸缺乏、高同型半胱氨酸血症和血清GPCA阳性。78例小细胞增多/OLP患者和510例非小细胞增多/OLP患者的血红蛋白、血清铁和维生素B12缺乏症、高同型半胱氨酸血症和血清GPCA阳性频率均显著高于588名健康对照者（p值均为0.001）。此外，78例小细胞增多/OLP患者血红蛋白和血清铁缺乏的频率明显高于510例非小细胞增多/OLP患者。结论78例小细胞增多/OLP患者和510例非小细胞增多/OLP患者的贫血、血清铁和维生素B12缺乏症、高同型半胱氨酸血症和血清GPCA阳性发生率明显高于588例健康对照者。此外，78例小细胞增多/OLP患者血红蛋白和血清铁缺乏的频率也明显高于510例非小细胞增多/OLP患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Dental Sciences 医学-牙科与口腔外科

CiteScore

5.10

自引率

14.30%

发文量

348

审稿时长

6 days

期刊介绍： he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.