Associations of dietary habits, inflammatory dietary index, and lifestyle factors with depressive symptoms: A cross-sectional study of 53,539 individuals with thyroid nodules

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-06-20 DOI:10.1016/j.jad.2025.119735

Lijun Li , Ying Li , Hui Li , Yi Zhou , Xue He , Pingting Yang , Xingxing Wang , Jiayi Zhu , Yinglong Duan , Jianfei Xie , Andy S.K. Cheng

{"title":"Associations of dietary habits, inflammatory dietary index, and lifestyle factors with depressive symptoms: A cross-sectional study of 53,539 individuals with thyroid nodules","authors":"Lijun Li , Ying Li , Hui Li , Yi Zhou , Xue He , Pingting Yang , Xingxing Wang , Jiayi Zhu , Yinglong Duan , Jianfei Xie , Andy S.K. Cheng","doi":"10.1016/j.jad.2025.119735","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Depressive symptoms are closely associated with thyroid nodules (TNs). Lifestyle and dietary factors have been linked to depressive symptoms. Therefore, this study aimed to investigate the associations between dietary patterns-including dietary diversity, protein-enriched dietary, inflammatory dietary patterns, dietary habits and depressive symptoms in individuals with TNs.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 53,539 participants who underwent physical examinations between January 2017 and March 2024. Participants completed self-reported questionnaires on demographic characteristics, physical health, activity levels, dietary index scores, dietary habits, and depressive symptoms.</div></div><div><h3>Results</h3><div>Participants were female (OR: 1.38, 95 % CI: 1.30–1.46), divorced or widowed (OR: 1.56, 95 % CI: 1.31–1.85), had a higher waist-hip ratio, and (OR: 2.22; 95 % CI: 1.43–3.43) and engaged in prolonged sedentary time (OR: 1.51; 95 % CI: 1.41–1.62) were more likely to report depressive symptoms. Regarding dietary factors, an anti-inflammatory dietary (OR: 0.79; 95 % CI: 0.75–0.83) and a protein-enriched dietary (OR: 0.87; 95 % CI: 0.83–0.92) were associated with a lower risk of depressive symptoms. However, irregular eating (OR: 2.00, 95 % CI: 1.81–2.21), overeating frequently (OR: 1.87; 95 % CI: 1.70–2.05), and being a former drinker (OR: 1.43, 95 % CI: 1.19–1.71) were associated with a higher risk of depressive symptoms in individuals with TNs.</div></div><div><h3>Conclusions</h3><div>Unhealthy eating behaviors and prolonged sedentary time were associated with a higher risk of depressive symptoms in individuals with TNs, while anti-inflammatory and protein-rich diets were associated with lower odds. These findings suggest potential links between dietary and lifestyle factors and depressive symptoms, which may warrant further investigation in prospective or interventional studies.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119735"},"PeriodicalIF":4.9000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of affective disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165032725011772","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Depressive symptoms are closely associated with thyroid nodules (TNs). Lifestyle and dietary factors have been linked to depressive symptoms. Therefore, this study aimed to investigate the associations between dietary patterns-including dietary diversity, protein-enriched dietary, inflammatory dietary patterns, dietary habits and depressive symptoms in individuals with TNs.

Methods

This cross-sectional study included 53,539 participants who underwent physical examinations between January 2017 and March 2024. Participants completed self-reported questionnaires on demographic characteristics, physical health, activity levels, dietary index scores, dietary habits, and depressive symptoms.

Results

Participants were female (OR: 1.38, 95 % CI: 1.30–1.46), divorced or widowed (OR: 1.56, 95 % CI: 1.31–1.85), had a higher waist-hip ratio, and (OR: 2.22; 95 % CI: 1.43–3.43) and engaged in prolonged sedentary time (OR: 1.51; 95 % CI: 1.41–1.62) were more likely to report depressive symptoms. Regarding dietary factors, an anti-inflammatory dietary (OR: 0.79; 95 % CI: 0.75–0.83) and a protein-enriched dietary (OR: 0.87; 95 % CI: 0.83–0.92) were associated with a lower risk of depressive symptoms. However, irregular eating (OR: 2.00, 95 % CI: 1.81–2.21), overeating frequently (OR: 1.87; 95 % CI: 1.70–2.05), and being a former drinker (OR: 1.43, 95 % CI: 1.19–1.71) were associated with a higher risk of depressive symptoms in individuals with TNs.

Conclusions

Unhealthy eating behaviors and prolonged sedentary time were associated with a higher risk of depressive symptoms in individuals with TNs, while anti-inflammatory and protein-rich diets were associated with lower odds. These findings suggest potential links between dietary and lifestyle factors and depressive symptoms, which may warrant further investigation in prospective or interventional studies.

查看原文本刊更多论文

饮食习惯、炎症性饮食指数和生活方式因素与抑郁症状的关联：53,539例甲状腺结节患者的横断面研究

背景：抑郁症状与甲状腺结节（TNs）密切相关。生活方式和饮食因素与抑郁症状有关。因此，本研究旨在探讨TNs患者饮食模式（包括饮食多样性、富含蛋白质的饮食、炎症性饮食模式、饮食习惯和抑郁症状）之间的关系。方法本横断面研究包括53539名参与者，他们在2017年1月至2024年3月期间接受了体检。参与者完成了关于人口特征、身体健康、活动水平、饮食指数得分、饮食习惯和抑郁症状的自我报告问卷。结果研究对象为女性（OR: 1.38, 95% CI: 1.30-1.46）、离婚或丧偶（OR: 1.56, 95% CI: 1.31-1.85）、腰臀比较高(OR: 2.22；95% CI: 1.43-3.43)和久坐时间(OR: 1.51；95% CI: 1.41-1.62)更有可能报告抑郁症状。在饮食因素方面，抗炎饮食(OR: 0.79；95% CI: 0.75-0.83)和富含蛋白质的饮食(OR: 0.87；95% CI: 0.83-0.92)与较低的抑郁症状风险相关。然而，饮食不规律（OR: 2.00, 95% CI: 1.81-2.21），频繁暴饮暴食(OR: 1.87；95% CI: 1.70-2.05)和曾经饮酒者（OR: 1.43, 95% CI: 1.19-1.71）与TNs患者出现抑郁症状的高风险相关。结论：不健康的饮食习惯和久坐时间与TNs患者抑郁症状的高风险相关，而抗炎和富含蛋白质的饮食与此相关的风险较低。这些发现表明饮食和生活方式因素与抑郁症状之间存在潜在联系，这可能需要在前瞻性或干预性研究中进一步调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.