The gray matter microstructure and psychological resilience in patients with depression: A preliminary study using DSI/NODDI imaging

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-06-19 DOI:10.1016/j.jpsychires.2025.06.032

Liaoming Gao , Zhiming Chen , Ziqi Wu , Junyan Wen , Zhujia Li , Ying Guo , Jingwen Luo , Liya Gong , Zhiting Chen , Lin Wang , Linlin Jing , Honglei Yin , Gen Wen

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引用次数: 0

Abstract

Background

Psychological resilience serves as a crucial protective factor against depression, yet its microstructural neuroimaging correlates remain poorly understood. This study aimed to investigate gray matter microstructural features associated with psychological resilience levels in patients with depression.

Methods

Sixty-four patients with depression underwent diffusion spectrum imaging (DSI) and neurite orientation dispersion and density imaging (NODDI). Derived metrics included fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD), isotropic volume fraction (FISO), intracellular volume fraction (FICVF), and orientation dispersion index (ODI). Voxel-based analysis was performed to assess correlations between imaging metrics and resilience scores, followed by partial correlation analysis of significant regional metrics.

Results

Positive correlations with resilience were observed for: AD in the posterior cingulate gyrus (CCG; r = 0.48, p < 0.001), AD in the right dorsal caudate (RDC; r = 0.45, p < 0.001), FA in the right inferior midfrontal gyrus junction (fMFG; r = 0.33, p = 0.009), and FICVF in the left anterior superior parietal lobule (SPL; r = 0.27, p = 0.030). Negative correlation was found for ODI in the right dorsal midfrontal gyrus (dMFG; r = −0.27, p = 0.030). Neurosynth meta-analysis revealed significant functional associations between these brain regions and the following cognitive domains.

Conclusion

Altered psychological resilience in depression shows close associations with gray matter microstructural changes, potentially explaining neuroanatomical mechanisms underlying resilience. These findings provide novel insights for clinical interventions targeting resilience enhancement.

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抑郁症患者脑灰质微观结构与心理弹性：DSI/NODDI成像的初步研究

心理弹性是对抗抑郁症的重要保护因素，但其显微结构神经影像学相关性仍然知之甚少。本研究旨在探讨抑郁症患者与心理弹性水平相关的灰质微观结构特征。方法对64例抑郁症患者进行弥散谱成像（DSI）和神经突定向弥散密度成像（NODDI）检查。衍生指标包括分数各向异性（FA）、平均扩散率（MD）、径向扩散率（RD）、轴向扩散率（AD）、各向同性体积分数（FISO）、细胞内体积分数（FICVF）和取向弥散指数（ODI）。基于体素的分析评估了成像指标与恢复能力评分之间的相关性，然后进行了显著区域指标的偏相关分析。结果：AD在扣带回后区（CCG）与恢复力呈正相关；R = 0.48, p <；0.001)，右侧尾状背侧AD (RDC；R = 0.45, p <；0.001)，右下额中回交界处FA (fMFG；r = 0.33, p = 0.009)，左侧顶叶前上小叶(SPL；R = 0.27, p = 0.030)。右额中回背侧ODI呈负相关；R =−0.27,p = 0.030)。神经合成元分析显示，这些大脑区域与以下认知领域之间存在显著的功能关联。结论抑郁症患者心理弹性的改变与灰质微观结构的改变密切相关，可能解释了心理弹性的神经解剖学机制。这些发现为针对恢复力增强的临床干预提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;