Organoids for tissue repair and regeneration

IF 8.7 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio Pub Date : 2025-06-23 DOI:10.1016/j.mtbio.2025.102013

Biao Yu , Dongyang Zhou , Fuxiao Wang , Xiao Chen , Mengmeng Li , Jiacan Su

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引用次数: 0

Abstract

Tissue damage and dysfunction are common consequences of various diseases and trauma, severely impacting patients' quality of life. Organoids, three-dimensional cell clusters formed through the self-organization of stem cells, not only recapitulate the developmental processes of native tissues but also exhibit remarkable plasticity and long-term expansion capabilities, demonstrating potential to overcome limitations of conventional therapeutic approaches. Particularly in addressing challenges such as immune rejection and regenerative efficiency, organoid technology has shown distinct advantages. This review summarizes the applications of organoids in tissue repair, including the biological principles and cultivation strategies of organoid culture, as well as their specific applications and preclinical research progress across diverse tissues (e.g., brain, liver, intestine, bone). Additionally, it discusses current challenges in organoid technology, such as large-scale production, heterogeneity control, and clinical translation, while outlining future development directions.

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用于组织修复和再生的类器官

组织损伤和功能障碍是各种疾病和创伤的常见后果，严重影响患者的生活质量。类器官是由干细胞自组织形成的三维细胞团，不仅概括了天然组织的发育过程，而且表现出显著的可塑性和长期扩张能力，显示出克服传统治疗方法局限性的潜力。特别是在解决免疫排斥和再生效率等挑战时，类器官技术显示出明显的优势。本文综述了类器官在组织修复中的应用，包括类器官培养的生物学原理和培养策略，以及它们在不同组织（如脑、肝、肠、骨）中的具体应用和临床前研究进展。此外，它还讨论了目前类器官技术面临的挑战，如大规模生产、异质性控制和临床翻译，同时概述了未来的发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).