Antibacterial activity and interfacial adsorption properties of quaternary-ammonium-salt-based gemini and trimeric surfactants

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications Pub Date : 2025-06-24 DOI:10.1016/j.colcom.2025.100850

Risa Kawai , Aya Furuichi , Shiho Yada , Hideyuki Kanematsu , Tomokazu Yoshimura

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Abstract

Quaternary-ammonium-salt-based surfactants are widely used as antibacterial agents and disinfectants. However, the factors affecting their antibacterial properties remain unclear. This study was aimed at investigating the relationship between antibacterial properties against Escherichia coli (E. coli) and Staphylococcus epidermidis (S. epidermidis) and wettability on polyethylene terephthalate (PET) surfaces. The analysis involved a quaternary-ammonium-salt-based gemini surfactant, and linear- and star-type trimeric surfactants. The gemini surfactant exhibited the highest antibacterial activities, likely due to its structural similarity to lipid molecules composing cell membranes. The linear-type trimeric surfactant exhibited higher antibacterial activity against E. coli than the star-type surfactant. Wettability analysis indicated that a correlation between increased surface adsorption on PET and enhanced antibacterial properties. Furthermore, the gemini and trimeric surfactants significantly inhibited S. epidermidis biofilm formation. This suggests that the strong interfacial adsorption of these surfactants, in addition to their ability to lower surface tension at the air/water interface, contributes to their antibiofilm properties.

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季铵盐基双子和三聚体表面活性剂的抗菌活性和界面吸附性能

季铵盐基表面活性剂被广泛用作抗菌剂和消毒剂。然而，影响其抗菌性能的因素尚不清楚。本研究旨在探讨对大肠杆菌（E. coli）和表皮葡萄球菌（S. epidermidis）的抗菌性能与聚对苯二甲酸乙二醇酯（PET）表面润湿性的关系。分析涉及季铵盐基双子表面活性剂，线性和星型三聚体表面活性剂。gemini表面活性剂表现出最高的抗菌活性，可能是由于其结构与构成细胞膜的脂质分子相似。线形三聚体表面活性剂对大肠杆菌的抑菌活性高于星形表面活性剂。润湿性分析表明，增加PET表面吸附与增强抗菌性能之间存在相关性。双子表面活性剂和三聚体表面活性剂显著抑制表皮葡萄球菌生物膜的形成。这表明，这些表面活性剂的强界面吸附，以及它们在空气/水界面上降低表面张力的能力，有助于它们的抗生物膜性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colloid and Interface Science Communications Materials Science-Materials Chemistry

CiteScore

9.40

自引率

6.70%

发文量

125

审稿时长

43 days

期刊介绍： Colloid and Interface Science Communications provides a forum for the highest visibility and rapid publication of short initial reports on new fundamental concepts, research findings, and topical applications at the forefront of the increasingly interdisciplinary area of colloid and interface science.