The association of Yarrowia lipolytica with onychomycosis

IF 1.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Julia R. Major , Claire A. Warren , Paul A. Rowley
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引用次数: 0

Abstract

Onychomycosis, a common fungal nail infection, is typically caused by dermatophytes or Candida species, but rare fungal pathogens can also be involved. We describe a 20-year-old woman with persistent nail shedding who was unresponsive to standard antifungal treatments. Microscopic nail examination, fungal culture, and ITS sequencing repeatedly identified the presence of Yarrowia lipolytica (formerly Candida lipolytica), a dimorphic yeast more often associated with systemic bloodstream infections and not previously identified in patients with onychomycosis. Susceptibility testing revealed the resistance of Y. lipolytica isolates to multiple antifungal azoles, complicating future treatment strategies for the patient. Commonly found in hydrocarbon-rich environments and an important organism for biotechnology, Y. lipolytica has industrial applications but is also capable of causing opportunistic infections in vulnerable patient populations. This case highlights the importance of thorough microbial identification and susceptibility testing in cases of treatment-resistant onychomycosis.
脂肪肝耶氏菌与甲癣的关系
甲真菌病是一种常见的指甲真菌感染,通常由皮肤真菌或念珠菌引起,但也可能涉及罕见的真菌病原体。我们描述了一名20岁的女性,指甲持续脱落,对标准抗真菌治疗无反应。指甲显微镜检查、真菌培养和ITS测序反复发现了脂性耶氏菌(以前的脂性念珠菌)的存在,这是一种二态酵母菌,通常与全身血流感染有关,以前未在甲癣患者中发现。药敏试验显示,脂肪瘤Y. polytica分离物对多种抗真菌唑类药物具有耐药性,这使患者未来的治疗策略复杂化。通常存在于富含碳氢化合物的环境中,是一种重要的生物技术生物,它具有工业应用,但也能够在脆弱的患者群体中引起机会性感染。该病例强调了在耐药甲癣病例中进行彻底的微生物鉴定和药敏试验的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Medical Mycology Case Reports
Medical Mycology Case Reports MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
4.00
自引率
0.00%
发文量
48
审稿时长
47 days
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