The Yin and Yang of replicative aging and rejuvenation

IF 3.6 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2025-06-23 DOI:10.1016/j.gde.2025.102375

Wei-Han Lin , Aliaksandr Damenikan , Yves Barral

引用次数: 0

Abstract

Budding yeast undergoes replicative aging through asymmetric cell divisions. Yeast mother cells progressively age as they generate successive daughter cells, until they ultimately die. However, their daughters are born rejuvenated, that is, most of them recover a full lifespan potential, with little impact of their mothers’ age at their birth. In this review, we will discuss recent findings regarding the mechanisms of replicative aging and rejuvenation. Based on these insights, we will also discuss which evolutionary forces may have presided over the emergence of aging in yeast. We suggest that aging and rejuvenation represent two adaptive strategies that each bring their own benefits.

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生殖衰老和返老还童的阴阳

出芽酵母通过不对称的细胞分裂进行复制老化。酵母母细胞在产生连续的子细胞的过程中逐渐衰老，直到最终死亡。然而，他们的女儿出生时充满活力，也就是说，她们中的大多数人恢复了完整的生命潜力，几乎没有受到母亲出生时年龄的影响。在这篇综述中，我们将讨论关于复制衰老和返老返老机制的最新发现。基于这些见解，我们还将讨论哪些进化力量可能主持了酵母衰老的出现。我们认为衰老和返老还老是两种适应性策略，它们各自带来好处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)