Menstrual bleeding-specific quality of life in women on antiplatelet therapy

IF 3.4 3区 医学 Q2 HEMATOLOGY
Eva K. Kempers , Johanna A. van der Zande , Paula M. Janssen , Jérôme M.J. Cornette , Jolien W. Roos–Hesselink , Marieke J.H.A. Kruip
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Abstract

Background

Antiplatelet therapy may affect menstrual blood loss in women of reproductive age.

Objectives

To determine menstrual bleeding and related quality of life (QoL) in women on antiplatelet therapy.

Methods

We performed a cross-sectional study at a tertiary care center in the Netherlands, including women on antiplatelet therapy with an active menstrual cycle and a control group of reproductive-aged women who did not use antiplatelets. Participants completed an online questionnaire containing 2 validated instruments: (1) the Menstrual Bleeding Questionnaire (MBQ) to measure menstrual bleeding-specific QoL, and (2) the Pictorial Blood Loss Assessment Chart (PBAC). Scaled MBQ scores range from 0 to 100, with higher scores indicating worse QoL. A PBAC score of 100 is generally considered indicative of heavy menstrual bleeding.

Results

In total, 38 women prescribed antiplatelet drugs (median age, 44 years [IQR, 40-48]) and 100 control women (median age, 35 years [IQR, 27-43]) completed the study questionnaire. Most common indication for antiplatelet therapy was stroke/transient ischemic attack (26%). Acetylsalicylic acid/carbasalate calcium (50%) and clopidogrel (37%) were most frequently used. Mean (SD) scaled MBQ scores were 18.9 (11.2) among antiplatelet drug users and 22.4 (10.9) in control women (adjusted mean difference, −3.28 [95% CI, −7.90, 1.35]). Median PBAC scores were 101.5 (IQR, 50.5-207) and 96.0 (IQR, 73.0-174.8; adjusted mean ratio, 0.784 [95% CI, 0.521, 1.18]), respectively. A PBAC score >100 was reported in 37% and 36% of the antiplatelet and control groups, respectively.

Conclusion

Menstrual bleeding-specific QoL was comparable between women on antiplatelet therapy and controls, although controls experienced a high burden of menstrual bleeding-related complaints. Menstrual blood loss did not seem to be increased.
经期出血对抗血小板治疗妇女生活质量的影响
背景:抗血小板治疗可能影响育龄妇女的经血流失。目的了解抗血小板治疗妇女月经出血及相关生活质量。方法:我们在荷兰的一家三级保健中心进行了一项横断面研究,包括月经周期活跃且接受抗血小板治疗的妇女和未使用抗血小板治疗的育龄妇女对照组。参与者完成了一份在线问卷,其中包含两种经过验证的工具:(1)月经出血问卷(MBQ),用于测量月经出血特异性生活质量(QoL);(2)失血图像评估表(PBAC)。MBQ量表得分范围从0到100,分数越高表明生活质量越差。PBAC评分为100分通常被认为是月经大量出血的迹象。结果共有38名服用抗血小板药物的女性(中位年龄44岁[IQR, 40-48])和100名对照女性(中位年龄35岁[IQR, 27-43])完成了研究问卷。抗血小板治疗最常见的适应症是中风/短暂性脑缺血发作(26%)。乙酰水杨酸/羧酸钙(50%)和氯吡格雷(37%)是最常用的药物。抗血小板药物使用者的平均(SD) MBQ评分为18.9分(11.2分),对照组为22.4分(10.9分)(调整后的平均差异为- 3.28 [95% CI, - 7.90, 1.35])。PBAC评分中位数为101.5 (IQR, 50.5-207)和96.0 (IQR, 73.0-174.8);调整后的平均比值分别为0.784 [95% CI, 0.521, 1.18])。抗血小板组和对照组的PBAC评分分别为37%和36%。结论经期出血特异性生活质量在接受抗血小板治疗的女性和对照组之间具有可比性,尽管对照组的经期出血相关投诉负担较高。月经失血量似乎没有增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.60
自引率
13.00%
发文量
212
审稿时长
7 weeks
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