{"title":"GreenScore: A User-Friendly Tool for Assessing the Sustainability of Chemical Processes","authors":"Frédéric Pin*, Julien Picard* and Sylvie Dhulut*, ","doi":"10.1021/acs.oprd.5c00047","DOIUrl":null,"url":null,"abstract":"<p >As the demand for more sustainable active pharmaceutical ingredients (APIs) grows, tools are needed to evaluate the environmental impacts of chemical processes. Herein, we describe the development of our internal tool, GreenScore, and the rationale behind the selection of metrics used to generate the most relevant score for a given chemical step. After a first version combining classical metrics based on the 12 principles of green chemistry, we worked with life cycle assessment experts from Quantis to fine-tune it, integrating the carbon footprint and the impact on biodiversity within the process evaluation. To support sustainability-driven process development, we introduce the GreenCard, a one-page summary that provides a clear overview of the sustainability of an entire synthesis and highlights areas for further improvement.</p>","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"29 7","pages":"1715–1726"},"PeriodicalIF":3.5000,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Process Research & Development","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.oprd.5c00047","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
As the demand for more sustainable active pharmaceutical ingredients (APIs) grows, tools are needed to evaluate the environmental impacts of chemical processes. Herein, we describe the development of our internal tool, GreenScore, and the rationale behind the selection of metrics used to generate the most relevant score for a given chemical step. After a first version combining classical metrics based on the 12 principles of green chemistry, we worked with life cycle assessment experts from Quantis to fine-tune it, integrating the carbon footprint and the impact on biodiversity within the process evaluation. To support sustainability-driven process development, we introduce the GreenCard, a one-page summary that provides a clear overview of the sustainability of an entire synthesis and highlights areas for further improvement.
期刊介绍：
The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
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