Huihai Zhong, Kexuan Nie, Manman Zheng, Yujie Wang*, Guohui Nie* and Bin Zhang*,
{"title":"Rational Design of Nanozymes for Tumor Therapy─A Perspective","authors":"Huihai Zhong, Kexuan Nie, Manman Zheng, Yujie Wang*, Guohui Nie* and Bin Zhang*, ","doi":"10.1021/acsami.5c08400","DOIUrl":null,"url":null,"abstract":"<p >Nanozymes are nanomaterials with enzyme-like activities and have become a research hotspot in tumor therapy due to their exceptional properties. However, biological application of nanozymes remains a methodology and safety issue. More systematic and rational design of nanozymes is needed for better tumor treatment. In this Perspective, we focus on the key questions that need to be addressed in nanozyme research, including the catalytic mechanism elucidation and the construction of structure–activity relationship, and introduce several promising rational design methods as well as prospect the future development of nanozymes. This Perspective aims to help researchers clarify the rational design of nanozymes in tumor therapy, offering a comprehensive guide in this emerging field.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"17 26","pages":"37353–37361"},"PeriodicalIF":8.2000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Materials & Interfaces","FirstCategoryId":"88","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsami.5c08400","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Nanozymes are nanomaterials with enzyme-like activities and have become a research hotspot in tumor therapy due to their exceptional properties. However, biological application of nanozymes remains a methodology and safety issue. More systematic and rational design of nanozymes is needed for better tumor treatment. In this Perspective, we focus on the key questions that need to be addressed in nanozyme research, including the catalytic mechanism elucidation and the construction of structure–activity relationship, and introduce several promising rational design methods as well as prospect the future development of nanozymes. This Perspective aims to help researchers clarify the rational design of nanozymes in tumor therapy, offering a comprehensive guide in this emerging field.
期刊介绍：
ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
