The Association Between Maternal Asthma and Child Autism: A Systematic Review and Meta-Analysis

IF 5.6 2区 医学 Q1 BEHAVIORAL SCIENCES
Autism Research Pub Date : 2025-06-20 DOI:10.1002/aur.70071
Renee van der Schaaf, Vanessa E. Murphy, Soriah Harvey, Paige Dent, Alison Lane, Olivia Whalen
{"title":"The Association Between Maternal Asthma and Child Autism: A Systematic Review and Meta-Analysis","authors":"Renee van der Schaaf,&nbsp;Vanessa E. Murphy,&nbsp;Soriah Harvey,&nbsp;Paige Dent,&nbsp;Alison Lane,&nbsp;Olivia Whalen","doi":"10.1002/aur.70071","DOIUrl":null,"url":null,"abstract":"<p>Maternal asthma has been linked to child autism. In this study, we systematically reviewed observational studies published between July 2001 and February 2024 that assessed maternal asthma during pregnancy (exposure) and child autism (outcome). Databases searched included MEDLINE, CINAHL, EMBASE, and PsycINFO. Of the 350 potential studies, 19 met the inclusion criteria (2,530,716 participants; 73,065 autistic participants). Quality was assessed with the Newcastle–Ottawa Scale. Meta-analyses using proportions and odds ratios were conducted using the Mantel–Haenszel method with a random-effects model. Compared to women without asthma, there was an increased odds of child autism with any history of maternal asthma (OR = 1.32; 95% CI = 1.21, 1.44; <i>I</i><sup>2</sup> = 61%, <i>n</i> = 14), with current asthma during pregnancy (OR = 1.23; 95% CI = 1.12, 1.35; <i>I</i><sup>2</sup> = 35%, <i>n</i> = 10) and with medication use during pregnancy (OR = 1.48; 95% CI = 1.30, 1.68; <i>I</i><sup>2</sup> = 0%, <i>n</i> = 3). However, when women with asthma who used asthma medication were compared to those with asthma who did not use medication, there were no increased odds for child autism (OR = 1.07; 95% CI = 0.89, 1.27; <i>I</i><sup>2</sup> = 34%, <i>n</i> = 2). Maternal asthma is associated with an increased odds of child autism. Future studies should consider neurodivergence in the parents, the severity of asthma, and the effectiveness of prescribed medication in managing the mother's asthma to improve our understanding of this association.</p><p><b>Trial Registration:</b> PROSPERO registration: CRD42021265060</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 8","pages":"1630-1650"},"PeriodicalIF":5.6000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70071","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autism Research","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/aur.70071","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Maternal asthma has been linked to child autism. In this study, we systematically reviewed observational studies published between July 2001 and February 2024 that assessed maternal asthma during pregnancy (exposure) and child autism (outcome). Databases searched included MEDLINE, CINAHL, EMBASE, and PsycINFO. Of the 350 potential studies, 19 met the inclusion criteria (2,530,716 participants; 73,065 autistic participants). Quality was assessed with the Newcastle–Ottawa Scale. Meta-analyses using proportions and odds ratios were conducted using the Mantel–Haenszel method with a random-effects model. Compared to women without asthma, there was an increased odds of child autism with any history of maternal asthma (OR = 1.32; 95% CI = 1.21, 1.44; I2 = 61%, n = 14), with current asthma during pregnancy (OR = 1.23; 95% CI = 1.12, 1.35; I2 = 35%, n = 10) and with medication use during pregnancy (OR = 1.48; 95% CI = 1.30, 1.68; I2 = 0%, n = 3). However, when women with asthma who used asthma medication were compared to those with asthma who did not use medication, there were no increased odds for child autism (OR = 1.07; 95% CI = 0.89, 1.27; I2 = 34%, n = 2). Maternal asthma is associated with an increased odds of child autism. Future studies should consider neurodivergence in the parents, the severity of asthma, and the effectiveness of prescribed medication in managing the mother's asthma to improve our understanding of this association.

Trial Registration: PROSPERO registration: CRD42021265060

Abstract Image

母亲哮喘与儿童自闭症之间的关系:一项系统综述和荟萃分析。
母亲的哮喘与儿童自闭症有关。在这项研究中,我们系统地回顾了2001年7月至2024年2月期间发表的观察性研究,这些研究评估了怀孕期间母亲哮喘(暴露)和儿童自闭症(结果)。检索的数据库包括MEDLINE、CINAHL、EMBASE和PsycINFO。在350项潜在研究中,19项符合纳入标准(2,530,716名受试者;73065名自闭症参与者)。用纽卡斯尔-渥太华量表评估质量。采用随机效应模型的Mantel-Haenszel方法,采用比例和优势比进行meta分析。与没有哮喘的妇女相比,母亲有哮喘史的儿童患自闭症的几率增加(OR = 1.32;95% ci = 1.21, 1.44;I2 = 61%, n = 14),妊娠期有哮喘(OR = 1.23;95% ci = 1.12, 1.35;I2 = 35%, n = 10),与妊娠期间用药有关(OR = 1.48;95% ci = 1.30, 1.68;I2 = 0%, n = 3)。然而,当使用哮喘药物的哮喘妇女与不使用哮喘药物的哮喘妇女进行比较时,儿童自闭症的几率没有增加(OR = 1.07;95% ci = 0.89, 1.27;I2 = 34%, n = 2)。母亲患哮喘与儿童患自闭症的几率增加有关。未来的研究应该考虑父母的神经分化,哮喘的严重程度,以及治疗母亲哮喘的处方药物的有效性,以提高我们对这种关联的理解。试验注册:PROSPERO注册号:CRD42021265060。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Autism Research
Autism Research 医学-行为科学
CiteScore
8.00
自引率
8.50%
发文量
187
审稿时长
>12 weeks
期刊介绍: AUTISM RESEARCH will cover the developmental disorders known as Pervasive Developmental Disorders (or autism spectrum disorders – ASDs). The Journal focuses on basic genetic, neurobiological and psychological mechanisms and how these influence developmental processes in ASDs.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信