Rashid Saeed Abdo Hassen, Wahby Mohammed Babaresh, Irshad Ur Rehman, Zaid Talal, Maria Nayyar, Yazid Rettas, Syeda Javeria Shakeel, Sawaira Huriya, Aiman Begum, Oyoon Khan
{"title":"Association of XRCC1 Gene Polymorphism with an Increased Risk of Hepatocellular Carcinoma in the Peshawar Population.","authors":"Rashid Saeed Abdo Hassen, Wahby Mohammed Babaresh, Irshad Ur Rehman, Zaid Talal, Maria Nayyar, Yazid Rettas, Syeda Javeria Shakeel, Sawaira Huriya, Aiman Begum, Oyoon Khan","doi":"10.31557/APJCP.2025.26.6.2109","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the association between variations in the XRCC1 gene and the risk of hepatocellular carcinoma in individuals from Peshawar with chronic hepatitis C infection.</p><p><strong>Methods: </strong>The study included three groups of participants: 30 individuals with HCC resulting from chronic HCV infection, 30 participants with HCV-related cirrhosis, and 30 healthy controls. Detailed clinical and laboratory data were collected for all participants. The ARMS-PCR (Amplification Refractory Mutation System-Polymerase Chain Reaction) method was utilized to identify a single nucleotide polymorphism (SNP) in the XRCC1 gene.</p><p><strong>Result: </strong>The analysis revealed that HCC patients had a significantly higher occurrence of XRCC1 (AA and GA) genotypes and an increased frequency of the A allele compared to both cirrhotic HCV patients and healthy controls. Additionally, individuals with the XRCC1 (AA and GA) genotypes demonstrated greater tumor foci and larger tumor sizes. Multivariate analysis revealed that the XRCC1 rs25487 polymorphism independently contributes to a higher likelihood of developing HCC in patients with chronic HCV, with a 2.66-fold.</p><p><strong>Conclusion: </strong>The polymorphism of the XRCC1 gene is probably linked with an elevated risk of hepatocellular carcinoma in individuals with chronic HCV infection. These findings underscore the importance of genetic factors in assessing HCC risk.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 6","pages":"2109-2115"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Pacific Journal of Cancer Prevention","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31557/APJCP.2025.26.6.2109","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: This study aimed to examine the association between variations in the XRCC1 gene and the risk of hepatocellular carcinoma in individuals from Peshawar with chronic hepatitis C infection.
Methods: The study included three groups of participants: 30 individuals with HCC resulting from chronic HCV infection, 30 participants with HCV-related cirrhosis, and 30 healthy controls. Detailed clinical and laboratory data were collected for all participants. The ARMS-PCR (Amplification Refractory Mutation System-Polymerase Chain Reaction) method was utilized to identify a single nucleotide polymorphism (SNP) in the XRCC1 gene.
Result: The analysis revealed that HCC patients had a significantly higher occurrence of XRCC1 (AA and GA) genotypes and an increased frequency of the A allele compared to both cirrhotic HCV patients and healthy controls. Additionally, individuals with the XRCC1 (AA and GA) genotypes demonstrated greater tumor foci and larger tumor sizes. Multivariate analysis revealed that the XRCC1 rs25487 polymorphism independently contributes to a higher likelihood of developing HCC in patients with chronic HCV, with a 2.66-fold.
Conclusion: The polymorphism of the XRCC1 gene is probably linked with an elevated risk of hepatocellular carcinoma in individuals with chronic HCV infection. These findings underscore the importance of genetic factors in assessing HCC risk.
期刊介绍：
Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation.
The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally.
The APJCP publishes original research results under the following categories:
-Epidemiology, detection and screening.
-Cellular research and bio-markers.
-Identification of bio-targets and agents with novel mechanisms of action.
-Optimal clinical use of existing anti-cancer agents, including combination therapies.
-Radiation and surgery.
-Palliative care.
-Patient adherence, quality of life, satisfaction.
-Health economic evaluations.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
