Clinical characteristics and risk factors of premature rupture of membranes infection in pregnant and lying-in women

IF 3.7 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS
Shufang Xiao, Meimei Lin
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引用次数: 0

Abstract

Premature rupture of membranes is one of the more common symptoms of pregnant women before labor, which can lead to an increased rate of preterm birth and a higher mortality rate of the fetus born from it. The current research on premature rupture of membranes (PROM) is mainly based on multivariate regression analysis, and variables are selected for multivariate regression analysis after univariate analysis. This method may omit some independent variables, resulting in one-sided analysis results. In this context, this study uses Bayesian method and Logistic regression analysis to construct a new variable analysis model to analyze the clinical characteristics and risk factors of PROM infection. First, through Bayesian Logistic regression, the clinical features of PROM infection mainly include fever, increased white blood cells and C-reactive protein, and increased fetal heart rate. The analysis of risk factors showed that pathogen infection, maternal pregnancy number, and scarred uterus were all risk factors for PROM infection. Finally, in order to explain the effect of the analysis model used in this paper, a nonparametric test, AUC value and ROC curve were used to compare the effect of Bayesian Logistic regression and Logistic regression. The results showed that the statistic value of Bayesian logistic regression was 0.177 higher than that of logistic regression, and the AUC value was 0.014 higher. That is, the performance of the Bayesian logistic regression model is better. The method used in the experiment is feasible, and the experimental results are in line with expectations.
妊娠和产妇胎膜早破感染的临床特点及危险因素。
胎膜早破是孕妇临产前较常见的症状之一,可导致早产率增加,由此产生的胎儿死亡率也较高。目前对膜早破(PROM)的研究主要基于多元回归分析,在单因素分析后选择变量进行多元回归分析。这种方法可能会遗漏一些自变量,导致分析结果单侧。在此背景下,本研究采用贝叶斯方法和Logistic回归分析,构建新的变量分析模型,分析胎膜早破感染的临床特征及危险因素。首先,通过贝叶斯Logistic回归分析,胎膜早破感染的临床特征主要有发热、白细胞和c反应蛋白升高、胎心率升高。危险因素分析表明,病原菌感染、产妇妊娠数、瘢痕子宫均为胎膜早破感染的危险因素。最后,为了说明本文所采用的分析模型的效果,采用非参数检验、AUC值和ROC曲线对贝叶斯Logistic回归和Logistic回归的效果进行了比较。结果表明,贝叶斯logistic回归的统计值比logistic回归的统计值高0.177,AUC值高0.014。也就是说,贝叶斯逻辑回归模型的性能更好。实验采用的方法是可行的,实验结果符合预期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
SLAS Technology
SLAS Technology Computer Science-Computer Science Applications
CiteScore
6.30
自引率
7.40%
发文量
47
审稿时长
106 days
期刊介绍: SLAS Technology emphasizes scientific and technical advances that enable and improve life sciences research and development; drug-delivery; diagnostics; biomedical and molecular imaging; and personalized and precision medicine. This includes high-throughput and other laboratory automation technologies; micro/nanotechnologies; analytical, separation and quantitative techniques; synthetic chemistry and biology; informatics (data analysis, statistics, bio, genomic and chemoinformatics); and more.
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