Structural prediction of potent non-coding RNAs.

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Abhijit Beura, Gowrang Kasaba Manjunath, Tikam Chand Dakal, Abhishek Kumar
{"title":"Structural prediction of potent non-coding RNAs.","authors":"Abhijit Beura, Gowrang Kasaba Manjunath, Tikam Chand Dakal, Abhishek Kumar","doi":"10.1016/bs.pmbts.2025.05.002","DOIUrl":null,"url":null,"abstract":"<p><p>Non-coding RNAs (ncRNAs) are vital regulatory molecules that play critical roles in gene expression, cellular signaling, and various biological processes. This review explores the diverse types of ncRNAs, including microRNAs, small interfering RNAs, and long non-coding RNAs, emphasizing their structural features and functional implications. Accurate structural predictions of ncRNAs are essential for understanding their interactions with other biomolecules and developing therapeutic strategies. Advances in computational methods and experimental techniques are enhancing our ability to predict RNA structures and elucidate their roles in health and disease. Despite significant progress, challenges remain in accurately modeling complex RNA structures and understanding the dynamic nature of RNA folding. Future research directions will focus on integrating multi-omics data, refining prediction algorithms, and addressing ethical considerations associated with ncRNA-based therapies. The potential applications of ncRNAs in drug discovery, biomarker identification, and synthetic biology underscore their importance in modern biomedical research.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"214 ","pages":"101-143"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in molecular biology and translational science","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/bs.pmbts.2025.05.002","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/27 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0

Abstract

Non-coding RNAs (ncRNAs) are vital regulatory molecules that play critical roles in gene expression, cellular signaling, and various biological processes. This review explores the diverse types of ncRNAs, including microRNAs, small interfering RNAs, and long non-coding RNAs, emphasizing their structural features and functional implications. Accurate structural predictions of ncRNAs are essential for understanding their interactions with other biomolecules and developing therapeutic strategies. Advances in computational methods and experimental techniques are enhancing our ability to predict RNA structures and elucidate their roles in health and disease. Despite significant progress, challenges remain in accurately modeling complex RNA structures and understanding the dynamic nature of RNA folding. Future research directions will focus on integrating multi-omics data, refining prediction algorithms, and addressing ethical considerations associated with ncRNA-based therapies. The potential applications of ncRNAs in drug discovery, biomarker identification, and synthetic biology underscore their importance in modern biomedical research.

强效非编码rna的结构预测。
非编码rna (ncRNAs)是一种重要的调控分子,在基因表达、细胞信号传导和各种生物过程中发挥着关键作用。本文综述了不同类型的ncrna,包括microrna、小干扰rna和长链非编码rna,重点介绍了它们的结构特征和功能意义。准确预测ncrna的结构对于理解它们与其他生物分子的相互作用和制定治疗策略至关重要。计算方法和实验技术的进步正在增强我们预测RNA结构并阐明其在健康和疾病中的作用的能力。尽管取得了重大进展,但在准确建模复杂RNA结构和理解RNA折叠的动态性质方面仍然存在挑战。未来的研究方向将集中于整合多组学数据,改进预测算法,并解决与基于ncrna的治疗相关的伦理问题。ncrna在药物发现、生物标志物鉴定和合成生物学方面的潜在应用凸显了它们在现代生物医学研究中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
6.90
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信