Time-Dependent Apparent Diffusion Coefficient Changes in Breast MR Images With Contrast for Tumor Characterization.

IF 2.5 3区医学 Q2 ONCOLOGY

Clinical breast cancer Pub Date : 2025-05-28 DOI:10.1016/j.clbc.2025.05.019

Yongsheng Ao, Xuanle Li, Lan Mu, Jierui Zhao, Hongliang Chen, Yunling Wang, Shuheng Zhang, Shimin Yang, Na Zhang, Lihua Qiu

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引用次数: 0

Abstract

Background: To assess the effect of scan time after contrast injection on breast MRI DWI sequence ADC values and its role in lesion differentiation.

Patients and methods: Between 2022 and 2023, two hundred and fifty-one breast magnetic resonance (MR) images were collected from 251 patients, who had a total of 258 lesions. Pathology results obtained within 1 month of the MR imaging were utilized. Apparent diffusion coefficient (ADC) values were measured at 3 time-points: precontrast, 3 minutes postcontrast, and 6 minutes postcontrast. For the analysis, statistical methods including the Friedman test, linear mixed models, Bonferroni correction, receiver operating characteristic (ROC) curve analysis, and DeLong test were applied.

Results: Contrast agents cause ADC values to decrease within 3 minutes after injection and recover within 6 minutes (e.g., invasive ductal carcinoma). ADC can distinguish between benign tumors and cancers but not between carcinoma in situ and invasive carcinoma. Time-dependent changes do not affect the differentiation of benign from malignant lesions.

Conclusion: Contrast injection time has little effect on the effectiveness of ADC in differentiating benign from malignant lesions on DWI sequences. The findings support the feasibility of postcontrast DWI without compromising diagnostic accuracy.

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乳腺MR图像随时间的表观扩散系数变化与肿瘤特征对比。

背景：探讨注射造影剂后扫描时间对乳腺MRI DWI序列ADC值的影响及其在病变鉴别中的作用。患者和方法：在2022年至2023年期间，收集了251例患者的251张乳房磁共振（MR）图像，共258个病变。使用磁共振成像后1个月内的病理结果。在对比前、对比后3分钟和对比后6分钟三个时间点测量表观扩散系数（ADC）值。分析采用Friedman检验、线性混合模型、Bonferroni校正、受试者工作特征（ROC）曲线分析、DeLong检验等统计方法。结果：造影剂可使ADC值在注射后3分钟内下降，6分钟内恢复（如浸润性导管癌）。ADC可以区分良性肿瘤和恶性肿瘤，但不能区分原位癌和浸润性癌。时间依赖性变化不影响良恶性病变的鉴别。结论：注射对比剂时间对ADC在DWI序列上鉴别良恶性病变的有效性影响不大。研究结果支持造影后DWI在不影响诊断准确性的情况下的可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical breast cancer 医学-肿瘤学

CiteScore

5.40

自引率

3.20%

发文量

174

审稿时长

48 days

期刊介绍： Clinical Breast Cancer is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of breast cancer. Clinical Breast Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of breast cancer. The main emphasis is on recent scientific developments in all areas related to breast cancer. Specific areas of interest include clinical research reports from various therapeutic modalities, cancer genetics, drug sensitivity and resistance, novel imaging, tumor genomics, biomarkers, and chemoprevention strategies.