Butch KuKanich, Kate KuKanich, Emily E Klocke, Micaela L Freeman, Alyson H Fitzgerald
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引用次数: 0
Abstract
Objective: To determine the perioperative efficacy and safety of methadone-fluconazole injection followed by oral methadone-fluconazole-naltrexone (methadone-fluconazole) compared to IM buprenorphine followed by oral codeine (buprenorphine).
Methods: Healthy dogs undergoing elective ovariohysterectomy or castration from October 2019 through December 2019 were blocked to treatment by week. The methadone-fluconazole group treatment included methadone-fluconazole (0.5 and 2.5 mg/kg, SC) preoperatively and once postoperatively; methadone-fluconazole-naltrexone (0.5, 2.5, and 0.125 mg/kg, PO, q 12 h) and an NSAID started approximately 24 hours after surgery. The buprenorphine group included buprenorphine preoperatively (0.02 mg/kg, IM) and postoperatively (0.01 mg/kg, IM), and then codeine (1 to 2 mg/kg, PO, q 8 h) and an NSAID started approximately 8 hours postoperatively. Preoperative sedation included acepromazine; anesthetic induction included ketamine-midazolam and isoflurane anesthesia. Faculty-supervised veterinary students performed the anesthesia and surgery. The Glasgow Composite Measure Pain Scale assessed postoperative pain; treatment failures included total pain scores > 5 (if nonmobile), > 6 (if mobile), and need for additional analgesia/sedation. Variables of interest were compared between groups.
Results: Enrollment included 119 dogs in the methadone-fluconaze group (47 male, 72 female) and 120 dogs in the buprenorphine group (44 male, 76 female). One dog was excluded (methadone-fluconazole) due to requiring additional surgery. Propofol was needed for anesthetic induction in 2 methadone-fluconazole and 8 buprenorphine dogs. Ephedrine was administered for intraoperative hypotension to 4 of 119 (methadone-fluconazole) and 8 of 120 (buprenorphine) dogs. One dog (methadone) received atropine. Mean ± SD postoperative rectal temperatures were significantly lower in methadone-fluconazole (35.6 ± 1.1 °C) than buprenorphine (36.1 ± 1.0 °C) dogs. Significantly more treatment failures occurred from buprenorphine (8 of 120) than methadone-fluconazole (1 of 119).
Conclusions: Methadone-fluconazole formulations provided superior clinical efficacy compared to buprenorphine.
Clinical relevance: Methadone-fluconazole formulations provide effective analgesia with twice-daily administration.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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