Prevalence, Risk Factors and Residential Variation Among HIV/TB Coinfected Mortality in Fenote Selam Hospital, Amhara Region: A Retrospective Study

Abstract

Background and Aim

HIV-TB co-infection is a worldwide health concern that arises when an individual has both HIV and tuberculosis (TB) infections. Ethiopia is one of the top 30 nations in the world with the highest rates of TB and HIV. The goal of this study was to determine the variables that influence adult HIV/TB coinfected patients’ mortality as well as the nutritional differences in mortality by level of residency.

Method

In this study, 417 patients that met our criteria were included in this study. We employed a multilevel logistic regression model.

Result

12.9% of HIV/TB coinfected patients died during the research period. It was discovered that important predictors of HIV/TB coinfected mortality included functional status, age of patients, WHO clinical stages, nutritional status, CD4 levels, regimen, and BMI. In our study, patients who fell into the bedridden functional status group, those who were in the fourth WHO clinical stage (stage IV), those who were older, those whose therapies were second-line regimens, and those with low CD4 cell counts were greater at risk of passing away.

Conclusion

This study showed that, individuals with HIV/TB co-infection were more likely to die and that this risk varied depending on the patient's place of residency (rural areas were more at risk).