An Energy Metabolism Nanoblocker for Cutting Tumor Cell Respiration and Inhibiting Mitochondrial Hijacking from Cytotoxic T Lymphocyte (Adv. Healthcare Mater. 16/2025)

Abstract

Metabolic Nanoblocker for Cancer Therapy

Tumor cells rely heavily on continuously generating energy for proliferation and metastasis. In article 2405174, Xingsheng Li, Zhigang Wang, Min Ge, Han Lin, and co-workers develop a CD44 receptor-targeted hyaluronic acid energy metabolism nanoblocker. This emerging strategy involves depleting tumor cell energy through the inhibition of basal respiration (OXPHOS/glycolysis) and extra respiration, while also synergistically enhancing effector immune cells to maintain systemic anti-tumor immune effects.