Inside Front Cover: Identification of an Activity Selector for the Nitroso-Forming Activity in Bacterial Type-III Copper Enzymes (Angew. Chem. 26/2025)
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Abstract
Enzyme specificity defines function: aminophenol oxidase uniquely converts aminophenols into nitrosophenols, whereas tyrosinase transforms them into quinone imines. This distinction is governed by a key amino acid near the copper(A) active site. In their Research Article (e202501560), Annette Rompel et al. demonstrated that a single amino acid exchange—swapping asparagine in SgGriF with isoleucine in SzTYR—can effectively invert the enzymes’ functions.
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