Longitudinal study of body mass index in relation to Alzheimer's disease pathology and symptomatology in Down syndrome

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-06-22 DOI:10.1002/alz.70387

Victoria L. Fleming, Brian C. Helsel, Lauren T. Ptomey, Benjamin L. Handen, Sharon J. Krinsky-McHale, Christy L. Hom, Matthew Zammit, Davneet Minhas, Weiquan Luo, Charles Laymon, Joseph H. Lee, Ira Lott, Annie Cohen, Beau M. Ances, Adam M. Brickman, Margaret Pulsifer, Isabel C. H. Clare, H. Diana Rosa, Florencia Lai, Jordan Harp, Fredrick Schmitt, Julie Price, Shahid H. Zaman, Elizabeth Head, Mark Mapstone, Bradley T. Christian, Ozioma Okonkwo, Sigan L. Hartley, Alzheimer's Biomarkers Consortium–Down Syndrome

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引用次数: 0

Abstract

INTRODUCTION

Weight loss has been linked to early Alzheimer's disease (AD) pathology, possibly through metabolic dysregulation. We examined changes in body mass index (BMI) in relation to AD biomarkers (amyloid beta [Aβ] and tau) and cognitive decline in adults with Down syndrome (DS). We hypothesized that BMI decline would track with early AD pathology and cognitive decline.

METHODS

Adults with DS (N = 467; M_age= 43.67 ± 10.06) completed one to four data cycles (≈16 months apart). Linear mixed models examined BMI change over time by age, positron emission tomography (PET) Aβ and tau, and changes in memory and dementia symptoms.

RESULTS

BMI declined with age-by-time (β = −0.014, p = 0.002) and baseline PET Aβ-by-time (β = −0.005, p = 0.002). On average, BMI decline began in the early 40s and was related to decline in memory and overall cognitive functioning.

DISCUSSION

Weight loss is associated with the presence of Aβ and cognitive decline in adults with DS. Longitudinal studies need to clarify directionality and biological mechanisms.

Highlights

Adults with Down syndrome (DS) are at an elevated risk for Down Syndrome assocaited Alzheimer's disease (DSAD).
On average, adults with DS experience body mass index (BMI) decline beginning in their early 40s.
Positron emission tomography amyloid beta deposition is associated with greater decline in BMI in adults with DS.
Across time, AD-related memory declines are associated with BMI decline.
BMI decline should be part of DSAD screening tools, as it is an important part of DSAD clinical disease expression.

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体重指数与唐氏综合征患者阿尔茨海默病病理和症状的纵向研究

体重减轻与早期阿尔茨海默病（AD）病理有关，可能与代谢失调有关。我们研究了患有唐氏综合症（DS）的成人体重指数（BMI）与AD生物标志物（淀粉样蛋白β [Aβ]和tau）和认知能力下降的关系。我们假设BMI下降与早期AD病理和认知能力下降有关。方法成人DS患者(N = 467；Mage = 43.67±10.06)完成1 ~ 4个数据周期（间隔约16个月）。线性混合模型通过年龄、正电子发射断层扫描（PET） Aβ和tau，以及记忆和痴呆症状的变化来检测BMI随时间的变化。结果BMI随年龄增长而下降（β = - 0.014, p = 0.002），基线PET a β随时间增长而下降（β = - 0.005, p = 0.002）。平均而言，体重指数的下降始于40岁出头，并与记忆力和整体认知功能的下降有关。成人退行性痴呆患者体重减轻与Aβ的存在和认知能力下降有关。纵向研究需要澄清方向性和生物学机制。患有唐氏综合症（DS）的成年人患唐氏综合症相关阿尔茨海默病（DSAD）的风险升高。平均而言，患有退行性痴呆的成年人在40岁出头时身体质量指数（BMI）开始下降。正电子发射断层扫描淀粉样蛋白沉积与成人退行性椎体滑移患者BMI下降幅度较大相关。随着时间的推移，与ad相关的记忆力下降与BMI下降有关。BMI下降是DSAD临床疾病表达的重要组成部分，应作为DSAD筛查工具的一部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.