Harnessing Crystallization-Driven Self-Assembly (CDSA) of Semicrystalline Block Copolymers for Functional 2D Architectures and Their Applications

Abstract

2D micelles have attracted considerable attention in materials science due to their high surface area, tunable surface properties, and diverse potential applications. Although various methods are well-established for synthesizing 2D inorganic materials, the development of 2D organic materials remains less advanced due to challenges in achieving controlled synthesis. Crystallization-driven self-assembly (CDSA) has emerged as a powerful and adaptable approach for constructing 2D micellar structures with precise control over dimensions, morphology, and corona chemistry. This technique is particularly significant for creating functional 2D architectures with applications across tissue engineering, nanomedicine, and sensing. Recent advances in CDSA of block copolymers have enabled enhanced structural precision and reproducibility, making it a valuable tool for designing next-generation 2D materials. This review provides a comprehensive overview of the current principles, properties, and application potential of 2D micelles with crystalline cores formed through CDSA, highlighting the transformative impact of this approach in the field of soft matter and nanotechnology.