{"title":"Generalized Boosted Models to Measure Racial Effects at Different Quantiles in Observational Studies","authors":"Lili Yue, Jiayue Zhang, Ping Yu, Gaorong Li","doi":"10.1002/bimj.70063","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>In this paper, we consider the estimation problem of treatment effect at different quantiles in observational studies with longitudinal data. The research motivation is from the NHLBI (National Heart, Lung, and Blood Institute) Growth and Health Study (NGHS), a longitudinal cohort study that aims to discuss the effects of race on cardiovascular risk factors. Because the true propensity score model is unknown, a nonparametric generalized boosted models (GBM) method is adopted to obtain the propensity score estimator. Combining the ideas of quantile regression and inverse probability weighting, a GBM-based quantile weighting estimation method is developed for the quantile treatment effect and applied in NGHS data to measure the racial effects at different quantiles. The results indicate that the racial effect varies with different quantile levels and may not equal to zero. Under various parameter configurations, some simulation studies are conducted to assess the effectiveness and advantages of our proposed estimation method compared with the existing approaches.</p></div>","PeriodicalId":55360,"journal":{"name":"Biometrical Journal","volume":"67 3","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biometrical Journal","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bimj.70063","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MATHEMATICAL & COMPUTATIONAL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In this paper, we consider the estimation problem of treatment effect at different quantiles in observational studies with longitudinal data. The research motivation is from the NHLBI (National Heart, Lung, and Blood Institute) Growth and Health Study (NGHS), a longitudinal cohort study that aims to discuss the effects of race on cardiovascular risk factors. Because the true propensity score model is unknown, a nonparametric generalized boosted models (GBM) method is adopted to obtain the propensity score estimator. Combining the ideas of quantile regression and inverse probability weighting, a GBM-based quantile weighting estimation method is developed for the quantile treatment effect and applied in NGHS data to measure the racial effects at different quantiles. The results indicate that the racial effect varies with different quantile levels and may not equal to zero. Under various parameter configurations, some simulation studies are conducted to assess the effectiveness and advantages of our proposed estimation method compared with the existing approaches.
期刊介绍:
Biometrical Journal publishes papers on statistical methods and their applications in life sciences including medicine, environmental sciences and agriculture. Methodological developments should be motivated by an interesting and relevant problem from these areas. Ideally the manuscript should include a description of the problem and a section detailing the application of the new methodology to the problem. Case studies, review articles and letters to the editors are also welcome. Papers containing only extensive mathematical theory are not suitable for publication in Biometrical Journal.