Acute toxicity and histopathological effects of pyriproxyfen in adult male and female zebrafish (Danio rerio)†

IF 3.5 Q3 ENGINEERING, ENVIRONMENTAL

Environmental science. Advances Pub Date : 2025-05-15 DOI:10.1039/D4VA00380B

Beatriz G. Gameiro, Rafaella S. Brito, Amanda de A. Valle, Flavio K. Tominaga, Fábio Kummrow, Gisele Giannocco, Dimitrius Leonardo Pitol, Nuha A. Dsouki, Rui M. de B. Maciel and Bruno F. Pereira

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Abstract

Pyriproxyfen (PPF) is a larvicide used to combat and control insects in agriculture, veterinary medicine and public health, particularly targeting vectors such as mosquitoes that transmit dengue fever. Despite being generally considered toxic to non-target organisms, the toxic effects of this substance have already been described. In this study, we investigated the effects of acute exposure (96 h) on the mortality and histopathology of different organs: the liver, gills, intestine, kidneys and gonads of adult individuals of the species Danio rerio. The results showed that the solubility of PPF prevents the accurate determination of LC_{50–96 h}; however, despite causing slight toxicity to female gills and gonads, the substance presented deleterious effects on the other tissues analyzed. We conclude that PPF proved to be toxic even in acute exposures; however, more studies with this substance should be expanded to chronic experiments.

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吡丙醚对成年雌雄斑马鱼（Danio rerio）的急性毒性和组织病理学影响

吡丙醚（PPF）是一种杀幼虫剂，用于防治农业、兽医和公共卫生领域的昆虫，特别是针对传播登革热的蚊子等病媒。尽管通常被认为对非目标生物有毒，但这种物质的毒性作用已经被描述过。在本研究中，我们研究了急性暴露（96 h）对达尼奥鱼（Danio rerio）成年个体的死亡率和不同器官（肝脏、鳃、肠道、肾脏和性腺）的组织病理学的影响。结果表明，PPF的溶解度影响了LC50-96 h的准确测定；然而，尽管对雌性鳃和性腺有轻微毒性，但该物质对所分析的其他组织有有害影响。我们的结论是，即使在急性暴露中，PPF也被证明是有毒的；然而，对这种物质的更多研究应该扩展到慢性实验。

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来源期刊

Environmental science. Advances

CiteScore

1.90

自引率

0.00%

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