Prevalence of reactive allergens in contact patch testing studies using the Brazilian standard battery: a systematic review

IF 3.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia Pub Date : 2025-06-23 DOI:10.1016/j.abd.2025.501126

Ana Laura Andrade Bueno , Nathalia Hoffmann Guarda Aguzzoli , Renan Rangel Bonamigo

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引用次数: 0

Abstract

Background

Contact dermatitis is a common dermatosis in dermatology. The patch test is the gold standard for diagnosis, using a panel of common allergens and irritants. In Brazil, a standardized battery of 30 substances is used. However, comprehensive epidemiological data on contact dermatitis are limited, and no studies have compiled and compared nationwide results.

Objectives

This study aimed to assess the positivity rate of patch tests using the Brazilian Standard Battery in suspected contact dermatitis cases from 2000 to 2022. We also evaluated associations between reactive substances and clinical and demographic variables and examined the variation in reactivity frequency to allergenic substances over the study period.

Methods

A systematic literature review was conducted using PubMed, Scielo, and LILACS. We evaluated the prevalence of positive tests for each substance, examined associations between variables such as gender, region, and age, and assessed variations in patch test positivity over time.

Results

Initially, 55 articles were identified, and 10 were included in the review. Nickel sulfate was the most frequently positive allergen, while triclosan, P-tertiary buthyphenol, and anthraquinone were the least prevalent. Test positivity increased every 5-years for kathon CG, neomycin, and nickel sulfate, while it decreased for quaternion 15 and thimerosal.

Study limitations

The results were limited by the small number of articles included in the review.

Conclusions

This pioneering study in Brazil provides valuable insights for dermatological allergy practitioners into the prevalence of patch test positivity for each substance in the Brazilian Standard Battery, aiding in informed decision-making and patient management.

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使用巴西标准电池的接触斑贴试验研究中反应性过敏原的流行：系统回顾

背景：接触性皮炎是皮肤科常见的皮肤病。斑贴试验是诊断的金标准，使用一组常见的过敏原和刺激物。在巴西，使用由30种物质组成的标准化电池。然而，关于接触性皮炎的全面流行病学数据有限，也没有汇编和比较全国结果的研究。目的本研究旨在评估2000 - 2022年疑似接触性皮炎病例中使用巴西标准电池进行斑贴试验的阳性率。我们还评估了反应性物质与临床和人口统计学变量之间的关系，并检查了在研究期间对致敏性物质的反应频率的变化。方法采用PubMed、Scielo、LILACS进行系统文献复习。我们评估了每种物质的阳性检测的普遍性，检查了性别、地区和年龄等变量之间的关联，并评估了斑贴试验阳性随时间的变化。结果最初，共识别55篇文章，其中10篇纳入综述。硫酸镍是最常见的阳性过敏原，而三氯生、对叔丁基酚和蒽醌是最不常见的。卡松CG、新霉素和硫酸镍的检测阳性每5年增加一次，季铵盐15和硫柳汞的检测阳性每5年下降一次。研究局限性：由于纳入综述的文章数量较少，研究结果受到限制。巴西的这项开创性研究为皮肤过敏医生提供了宝贵的见解，了解巴西标准电池中每种物质的斑贴试验阳性的流行程度，有助于知情决策和患者管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anais brasileiros de dermatologia DERMATOLOGY-

CiteScore

2.40

自引率

0.00%

发文量

184

审稿时长

32 days

期刊介绍： The journal is published bimonthly and is devoted to the dissemination of original, unpublished technical-scientific study, resulting from research or reviews of dermatological topics and related matters. Exchanges with other publications may be accepted.