An efficient synthesis of Indolo[3,2-c]coumarins by Pd-catalyzed intramolecular CH carbonylation

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-06-17 DOI:10.1016/j.tetlet.2025.155716

Hai-Bing Long, Xue-Hua Huang, Da-Xian You, Ye Liang, Jin-Bao Peng, Jia-Lei Yan, Ai-Jun Ma

引用次数: 0

Abstract

Indolo[3,2-c]coumarins, characterized by their distinctive fused heterocyclic architecture, demonstrate significant biological activities in natural settings. In this study, we report a Pd-catalyzed intramolecular CH carbonylation methodology for the synthesis of indolo[3,2-c]coumarins, and provide a straightforward approach for the total synthesis of natural product derivative and bioactive molecule of this class. This novel methodology provides a versatile platform for the comprehensive synthesis of indolo[3,2-c]coumarins.

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pd催化分子内CH羰基化高效合成吲哚[3,2-c]香豆素

吲哚[3,2-c]香豆素以其独特的融合杂环结构为特征，在自然环境中表现出重要的生物活性。在本研究中，我们报道了一种pd催化的分子内CH羰基化合成吲哚[3,2-c]香豆素的方法，为该类天然产物衍生物和生物活性分子的全合成提供了一种简单的方法。这种新颖的方法为吲哚[3,2-c]香豆素的综合合成提供了一个通用的平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.