Molecular evolution and spatial transmission of Dabieshan tick virus in Jilin Province, northeastern China

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-06-07 DOI:10.1016/j.isci.2025.112838

Ning Liu , Jingge Ma , Yu Liu , Yunzhi Peng , Ziyan Liu , Zheng Gui , Feng Wei , Liang Li , Bin Wang , Zedong Wang

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Abstract

Dabieshan tick virus (DBTV), a tick-borne virus belonging to the genus Uukuvirus in the family Phenuiviridae, exhibits potential pathogenicity to humans and animals. However, its geographic distribution and transmission dynamics remain poorly understood. In this study, we analyzed 1,352 ticks collected from Jilin Province, China, revealing DBTV prevalence rates of 20.8% in Haemaphysalis concinna and 23.6% in Haemaphysalis longicornis. Additionally, nine recombination events and 14 reassortment events were identified, suggesting close evolutionary relationships between Jilin strains and those from Shandong and Hubei provinces. Bayesian phylodynamic analysis indicates that DBTV likely originated in Hubei 13–80 years ago, subsequently spreading to Shandong and then to Jilin. This study provides critical epidemiological evidence and insights into the genetic evolution of DBTV in northeastern China.

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吉林省大别山蜱病毒的分子进化与空间传播

大别山蜱病毒（DBTV）是一种蜱传病毒，属于乌库病毒科乌库病毒属，对人类和动物具有潜在的致病性。然而，其地理分布和传播动态仍然知之甚少。本研究对吉林省采集的1352只蜱虫进行了分析，结果显示，在吉林血蜱和长角血蜱中，DBTV患病率分别为20.8%和23.6%。此外，鉴定出9个重组事件和14个重组事件，表明吉林菌株与山东和湖北的菌株具有密切的进化关系。贝叶斯系统动力学分析表明，DBTV可能起源于13 ~ 80年前的湖北，随后传播到山东，再传播到吉林。本研究为中国东北地区DBTV的遗传进化提供了重要的流行病学证据和见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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