Sonographic Hepatosplenic Ratio: A Noninvasive Method to Diagnose Graft Steatosis in Liver Transplantation

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings Pub Date : 2025-09-01 DOI:10.1016/j.transproceed.2025.05.007

Stefania Roselli , Piercarmine Panzera , Maria Filippa Valentini , Gianluigi Gigante , Irene Scalera , Grazia Labellarte , Oronzo Ligurgo , Nunzio Tralli , Francesco D’Amico , Francesco Tandoi

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引用次数: 0

Abstract

Liver steatosis is considered one of the most common disorders. Macrovesicular steatosis in donor livers is a major cause of graft failure and remains difficult to assess. The aim of this study is to evaluate the correlation between the hepato-splenic ratio (HSR) obtained by back table ultrasound (US) and the histological grade of graft steatosis, using liver biopsy as a reference. Between October 2019 and December 2021, 50 cadaveric liver transplant donors were studied. Back-table US was used to determine the HSR, which is obtained by dividing the mean brightness level of the liver region of interest by that of the splenic region. Biopsy was performed in all donors and fixed in 4% formalin. The histological variables analyzed were steatosis, fibrosis and inflammatory infiltrate. Spearman's coefficient was used to assess the correlation between the HSR and the presence of macrovesicular hepatic steatosis (r 0.28, P < .05). The cut-off of hepato-splenic ratio to predict steatosis is 0.91 (sensitivity 75% and specificity 57%). The mean ± SD of the ratio in the control and steatosis group were 0.9 ± 0.14 and 1.03 ± 0.3 (P = .11), respectively. The HSR can be a simple, objective and noninvasive method to assess the quality of the liver, which can be used in some contexts of liver procurement, when second-level imaging is not available or when liver biopsy is not possible.

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超声肝脾比：一种无创诊断肝移植移植脂肪变性的方法。

肝脂肪变性被认为是最常见的疾病之一。供体肝脏的大泡性脂肪变性是移植物失败的主要原因，目前仍难以评估。本研究的目的是评估肝脾比（HSR）通过背台超声（US）获得与移植脂肪变性的组织学分级之间的相关性，并以肝活检为参考。在2019年10月至2021年12月期间，对50名尸体肝移植供体进行了研究。使用backtable US来确定HSR， HSR是通过将感兴趣的肝脏区域的平均亮度水平除以脾脏区域的平均亮度水平得到的。所有供体均行活检，并用4%福尔马林固定。组织学变量分析为脂肪变性、纤维化和炎症浸润。采用Spearman系数评价HSR与大泡性肝脂肪变性的相关性（r 0.28, P < 0.05）。肝脾比值预测脂肪变性的临界值为0.91（敏感性75%，特异性57%）。对照组和脂肪变性组的平均±SD分别为0.9±0.14和1.03±0.3 （P = 0.11）。HSR是一种简单、客观、无创的评估肝脏质量的方法，可用于肝脏获取的某些情况，当无法获得二级成像或无法进行肝活检时。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplantation proceedings 医学-免疫学

CiteScore

1.70

自引率

0.00%

发文量

502

审稿时长

60 days

期刊介绍： Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics. Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board. Original basic or clinical science articles, clinical trials and case studies can be submitted to the journal?s open access companion title Transplantation Reports.