Recent developments in pharmacologic therapy of synovitis in osteoarthritis.

IF 2.2 3区医学 Q2 ORTHOPEDICS

Skeletal Radiology Pub Date : 2025-11-01 Epub Date: 2025-06-20 DOI:10.1007/s00256-025-04976-5

Francis Berenbaum

引用次数: 0

Abstract

Osteoarthritis (OA) is now considered an inflammatory disease in which synovitis has an active role in the generation of pain and structural progression. Despite attempts to reposition treatments for rheumatoid arthritis without conclusive success, synovitis remains a viable therapeutic target to slow progression and enhance the quality of life of OA patients. This review highlights the main targets explored today at the clinical and preclinical levels with the goal to not only relieve the symptoms but also to provide real disease modifying treatments that can prevent further joint damage and improve joint function by treating synovitis.

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骨关节炎滑膜炎的药物治疗进展。

骨关节炎（OA）现在被认为是一种炎症性疾病，其中滑膜炎在疼痛和结构进展的产生中起积极作用。尽管尝试重新定位治疗类风湿性关节炎没有决定性的成功，滑膜炎仍然是一个可行的治疗目标，以减缓进展和提高OA患者的生活质量。这篇综述强调了目前在临床和临床前水平上探索的主要目标，目的不仅是缓解症状，而且是提供真正的疾病修饰治疗，通过治疗滑膜炎来预防进一步的关节损伤和改善关节功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Skeletal Radiology 医学-核医学

CiteScore

4.40

自引率

9.50%

发文量

253

审稿时长

3-8 weeks

期刊介绍： Skeletal Radiology provides a forum for the dissemination of current knowledge and information dealing with disorders of the musculoskeletal system including the spine. While emphasizing the radiological aspects of the many varied skeletal abnormalities, the journal also adopts an interdisciplinary approach, reflecting the membership of the International Skeletal Society. Thus, the anatomical, pathological, physiological, clinical, metabolic and epidemiological aspects of the many entities affecting the skeleton receive appropriate consideration. This is the Journal of the International Skeletal Society and the Official Journal of the Society of Skeletal Radiology and the Australasian Musculoskelelal Imaging Group.