Association between triglyceride-glucose index and intracranial aneurysm rupture: findings from a retrospective study.

IF 2.5 3区医学 Q2 CLINICAL NEUROLOGY

Neurosurgical Review Pub Date : 2025-06-21 DOI:10.1007/s10143-025-03680-1

Jiancheng Lin, Xin Feng, Zhuohua Wen, Chi Huang, Mengshi Huang, Jiwan Huang, Runze Ge, Anqi Xu, Gengwu Ma, Hongyu Shi, Yuqi Hu, Hao Yuan, Can Li, Ruizhe Yi, Yuheng Jin, Shuyin Liang, Xin Zhang, Xifeng Li, Chuanzhi Duan

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引用次数: 0

Abstract

Background: Limited studies investigated the relationship between triglyceride-glucose (TyG) index and the rupture of intracranial aneurysm (IA). We aimed to examine the association between TyG index and IA rupture in patients diagnosed with IAs.

Materials and methods: Participants with IAs from January 2012 to April 2022 were retrospectively included. The association between TyG index and IA rupture was assessed by multivariable-adjusted logistic regression models, restricted cubic spline (RCS) models and subgroup analysis.

Results: Among 1535 patients with 1901 IAs, 596 (31.4%) IA rupture cases occurred. The incidence of IA rupture rose along with elevated TyG index. The positive correlation persisted after adjusting for age, sex, and other covariates, with adjusted odds ratios of 1.64 (95% CI 1.26-2.14) and 1.85 (95% CI 1.41-2.42) for TyG index tertiles 2 and 3. RCS curves showed a linear trend of TyG index with the risk of IA rupture. In the subgroup analysis, similar relationships were observed across subgroups defined by age, sex, hypertension, TC and aneurysm size.

Conclusions: There is a significant association between TyG index and the occurrence of IA rupture, indicating TyG index has the potential for risk assessment of IA rupture. Further prospective studies are warranted to validate its clinical utility.

Trial registration: ClinicalTrials.gov (NCT06456814). Registered on June 7, 2024.

查看原文本刊更多论文

甘油三酯-葡萄糖指数与颅内动脉瘤破裂之间的关系：一项回顾性研究的结果。

背景：有限的研究调查了甘油三酯-葡萄糖（TyG）指数与颅内动脉瘤破裂（IA）的关系。我们的目的是研究诊断为IAs的患者TyG指数与IA破裂之间的关系。材料和方法：回顾性纳入2012年1月至2022年4月期间的IAs患者。采用多变量调整logistic回归模型、限制性三次样条（RCS）模型和亚组分析评估TyG指数与IA破裂的相关性。结果：1535例1901例内陷患者中，发生内陷破裂596例（31.4%）。IA破裂的发生率随着TyG指数的升高而升高。在校正了年龄、性别和其他协变量后，正相关仍然存在，TyG指数2和3的校正优势比分别为1.64 （95% CI 1.26-2.14）和1.85 （95% CI 1.41-2.42）。RCS曲线显示TyG指数与IA破裂风险呈线性关系。在亚组分析中，以年龄、性别、高血压、TC和动脉瘤大小定义的亚组之间观察到相似的关系。结论：TyG指数与IA破裂的发生有显著相关性，提示TyG指数具有评估IA破裂风险的潜力。需要进一步的前瞻性研究来验证其临床应用。试验注册：ClinicalTrials.gov （NCT06456814）。登记日期为2024年6月7日。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurosurgical Review 医学-临床神经学

CiteScore

5.60

自引率

7.10%

发文量

191

审稿时长

6-12 weeks

期刊介绍： The goal of Neurosurgical Review is to provide a forum for comprehensive reviews on current issues in neurosurgery. Each issue contains up to three reviews, reflecting all important aspects of one topic (a disease or a surgical approach). Comments by a panel of experts within the same issue complete the topic. By providing comprehensive coverage of one topic per issue, Neurosurgical Review combines the topicality of professional journals with the indepth treatment of a monograph. Original papers of high quality are also welcome.