{"title":"Angiopoietins: multifaceted mediators in the pathogenesis of joint-related disorders.","authors":"Ruifeng Song, Zhebing Cheng, Zuping Wu, Guzhe Guan, Hengyuan Liu, Xiaoxia Feng, Qian Chen","doi":"10.1007/s00418-025-02395-0","DOIUrl":null,"url":null,"abstract":"<p><p>Joint-related diseases often involve multiple aspects of angiogenesis, alterations in the extracellular matrix (ECM), and inflammatory responses, causing pain and mobility problems for patients. Angiopoietins (Angs) are a protein family of secreted growth factors that have a variety of functions, including regulating angiogenesis, stabilizing blood vessels, and mediating changes in the ECM. The first Ang was discovered by Davis in COS cells, and since then, three more members of this protein family have been discovered. Among these four members, Ang-1 and Ang-2 play the most essential roles in joint diseases and are closely related to each other as ligands for the Tie-2 receptor. Ang-1 acts as an agonist at the Tie-2 receptor, while Ang-2 can act as either an agonist or antagonist of Tie-2 under specific conditions. This review describes the structure and general physiological functions of Angs and summarizes the role of Angs in joint-related diseases. It concludes with possible Ang-based therapeutic strategies.</p>","PeriodicalId":13107,"journal":{"name":"Histochemistry and Cell Biology","volume":"163 1","pages":"68"},"PeriodicalIF":2.1000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Histochemistry and Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s00418-025-02395-0","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Joint-related diseases often involve multiple aspects of angiogenesis, alterations in the extracellular matrix (ECM), and inflammatory responses, causing pain and mobility problems for patients. Angiopoietins (Angs) are a protein family of secreted growth factors that have a variety of functions, including regulating angiogenesis, stabilizing blood vessels, and mediating changes in the ECM. The first Ang was discovered by Davis in COS cells, and since then, three more members of this protein family have been discovered. Among these four members, Ang-1 and Ang-2 play the most essential roles in joint diseases and are closely related to each other as ligands for the Tie-2 receptor. Ang-1 acts as an agonist at the Tie-2 receptor, while Ang-2 can act as either an agonist or antagonist of Tie-2 under specific conditions. This review describes the structure and general physiological functions of Angs and summarizes the role of Angs in joint-related diseases. It concludes with possible Ang-based therapeutic strategies.
期刊介绍：
Histochemistry and Cell Biology is devoted to the field of molecular histology and cell biology, publishing original articles dealing with the localization and identification of molecular components, metabolic activities and cell biological aspects of cells and tissues. Coverage extends to the development, application, and/or evaluation of methods and probes that can be used in the entire area of histochemistry and cell biology.
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