Chronic obstructive pulmonary disease is a risk factor for non-tuberculous mycobacterial pulmonary disease: a population-based matched cohort study.

IF 3.4 3区 医学 Q1 RESPIRATORY SYSTEM
Jong Geol Jang, Hyun Lee, Min Gu Kang, Youlim Kim, Kwang Ha Yoo, Kyung Hoon Min, June Hong Ahn, Kyung Soo Hong, Jong Seung Kim, Ji-Yong Moon
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引用次数: 0

Abstract

Background: Longitudinal studies comprehensively evaluating the direction of the relationship between chronic obstructive pulmonary disease (COPD) and non-tuberculous mycobacterial pulmonary disease (NTM-PD) are scarce. Therefore, this study aimed to evaluate whether COPD influences the development of NTM-PD even after considering various confounders by using a nationwide longitudinal cohort study.

Methods: Data from the National Health Insurance Service National Sample Cohort between 2002 and 2019 were analysed. Participants≥20 years of age with COPD and no previous NTM diagnosis were included in the study. The incidence of NTM-PD was compared between participants with COPD (n=8939) and 1:4 fully matched control participants (n=32 355). Participants were followed until the date of NTM-PD incidence, death, or December 2019.

Results: During a median follow-up of 9.0 years (IQR, 5.0-12.9 years), participants with COPD (55.5 per 100 000 person-years) had a higher incidence of NTM-PD than matched control cohorts (25.4 per 100 000 person-years), with a HR of 2.16 (95% CI, 1.45 to 3.23). Age, sex, smoking history, asthma, bronchiectasis and corticosteroid use did not affect the association between COPD and the risk of incident NTM-PD (P for interaction >0.05 for all). Among patients with COPD, being underweight and having bronchiectasis were significantly associated with NTM-PD development.

Conclusions: Individuals with COPD had approximately a twofold increased risk of developing NTM-PD compared with matched controls. Being underweight and having bronchiectasis were identified as risk factors for developing NTM-PD.

Abstract Image

慢性阻塞性肺疾病是非结核性分枝杆菌肺病的危险因素:一项基于人群的匹配队列研究
背景:综合评价慢性阻塞性肺疾病(COPD)与非结核性分枝杆菌肺病(NTM-PD)关系方向的纵向研究很少。因此,本研究旨在通过一项全国性的纵向队列研究,在考虑了各种混杂因素后,评估COPD是否会影响NTM-PD的发展。方法:对2002年至2019年国民健康保险服务国家样本队列数据进行分析。年龄≥20岁的COPD患者,既往无NTM诊断纳入研究。比较COPD患者(n=8939)和1:4完全匹配对照组(n= 32355)之间NTM-PD的发病率。对参与者进行随访,直到NTM-PD发病、死亡或2019年12月。结果:在中位随访9.0年(IQR, 5.0-12.9年)期间,COPD患者(55.5 / 10万人-年)的NTM-PD发病率高于匹配对照队列(25.4 / 10万人-年),风险比为2.16 (95% CI, 1.45 - 3.23)。年龄、性别、吸烟史、哮喘、支气管扩张和皮质类固醇使用不影响COPD与NTM-PD发生风险之间的关联(相互作用P < 0.05)。在COPD患者中,体重过轻和支气管扩张与NTM-PD的发展显著相关。结论:与对照组相比,COPD患者发生NTM-PD的风险大约增加了两倍。体重过轻和支气管扩张被认为是NTM-PD的危险因素。
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来源期刊
BMJ Open Respiratory Research
BMJ Open Respiratory Research RESPIRATORY SYSTEM-
CiteScore
6.60
自引率
2.40%
发文量
95
审稿时长
12 weeks
期刊介绍: BMJ Open Respiratory Research is a peer-reviewed, open access journal publishing respiratory and critical care medicine. It is the sister journal to Thorax and co-owned by the British Thoracic Society and BMJ. The journal focuses on robustness of methodology and scientific rigour with less emphasis on novelty or perceived impact. BMJ Open Respiratory Research operates a rapid review process, with continuous publication online, ensuring timely, up-to-date research is available worldwide. The journal publishes review articles and all research study types: Basic science including laboratory based experiments and animal models, Pilot studies or proof of concept, Observational studies, Study protocols, Registries, Clinical trials from phase I to multicentre randomised clinical trials, Systematic reviews and meta-analyses.
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