Associations of handgrip strength asymmetry with physical frailty, cognitive impairment, and cognitive frailty: A cross-sectional finding from the Longitudinal Ageing Study in India (LASI), Wave 1 (2017-18)

IF 1.7 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2025-06-20 DOI:10.1016/j.cegh.2025.102108

Inderdeep Kaur , Nirmal Nath Upadhyay , Shivani Chandel

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引用次数: 0

Abstract

Objectives

As one ages, it becomes essential to anticipate and address the obstacles that impede the pursuit of healthy ageing. Thus, the present study aims to find out the associations between hand grip strength (HGS) asymmetry, physical frailty, cognitive impairment, and cognitive frailty.

Methods

The study utilizes Longitudinal Ageing Study in India (LASI) Wave-1 (2017–18) data. A total of 54,889 participants aged 45 years and above were included in the study. Physical frailty was assessed using the Modified Fried Frailty Phenotype and Cognitive impairment with the Composite Cognitive Impairment Index (CII). HGS asymmetry was calculated using hand grip ratios. Basic descriptive statistics were employed, and binary logistic regression confirmed the association between HGS asymmetry and cognitive frailty. Results at p < 0.05 were significant before and after adjusting for potential confounders.

Results

HGS asymmetry is strongly associated with physical frailty, cognitive impairment, and cognitive frailty. Participants with cognitive frailty had significantly higher odds of exhibiting greater HGS asymmetry, even after adjusting for confounders (AOR: 1.05, 95 % CI: 0.82–1.34, p < 0.01). Additionally, females exhibited a significantly higher prevalence of HGS asymmetry (59.9 %) (p < 0.01). Individuals living alone had the highest prevalence of cognitive frailty (5.5 %) (p < 0.01).

Conclusion

HGS asymmetry could strongly predict physical frailty, cognitive impairment, and cognitive frailty. Exercise-based intervention programs aiming to decrease HGS asymmetry and examine their impact on preventing physical frailty, cognitive impairment, and cognitive frailty should be developed and incorporated into various health policies designed with 'healthy ageing' in consideration.

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握力不对称与身体虚弱、认知障碍和认知虚弱的关联：来自印度纵向老龄化研究（LASI）的横断面发现，第1期（2017-18）

随着年龄的增长，预测和解决阻碍追求健康老龄化的障碍变得至关重要。因此，本研究旨在探讨握力不对称与身体虚弱、认知障碍和认知虚弱之间的关系。方法采用印度纵向老龄化研究（LASI） Wave-1（2017-18）数据。共有54,889名年龄在45岁及以上的参与者参与了这项研究。使用改良的Fried脆弱表型和复合认知障碍指数（CII）评估身体虚弱和认知障碍。HGS不对称是用手握比计算的。采用基本的描述性统计，二元逻辑回归证实了HGS不对称与认知脆弱之间的关联。p <；校正潜在混杂因素前后差异均有统计学意义。结果shgs不对称与身体虚弱、认知障碍和认知衰弱密切相关。认知脆弱的参与者表现出更大HGS不对称的几率显著更高，即使在调整混杂因素后也是如此(AOR: 1.05, 95% CI: 0.82-1.34, p <；0.01)。此外，女性的HGS不对称发生率显著高于男性（59.9%）(p <；0.01)。独居者的认知衰弱患病率最高（5.5%）(p <；0.01)。结论hgs不对称对体弱多病、认知障碍和认知衰弱有较强的预测作用。应该开发以运动为基础的干预项目，旨在减少HGS不对称，并检查其对预防身体虚弱、认知障碍和认知脆弱的影响，并将其纳入考虑到“健康老龄化”的各种卫生政策中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.