Drilling down to success: Comparative insight on single-drill and sequential-drill techniques for dental implant osseointegration using osteoprotegerin levels - A randomized control trial

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2025-06-22 DOI:10.1016/j.jobcr.2025.06.016

Jerome Rahul James, Karthigeyan Jeyapalan, Shanmuganathan Natarajan

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Abstract

Background

To evaluate and compare osteoblastic activity and osseointegration between single-drill and sequential-drill implant site preparation techniques, using osteoprotegerin (OPG) levels as a biomarker.

Methods

A randomized controlled trial with a split-mouth design was conducted, involving 12 participants (24 dental implants). The study included two groups: a single-drill group and a sequential-drill group. Gingival crevicular fluid samples were collected at baseline, 15-, 30- and 60-days post-implantation. Osteoprotegerin levels were measured using an enzyme-linked immunosorbent assay (ELISA).

Results

Intragroup analysis showed significant variations in OPG levels over time (p < 0.0001). Intergroup comparisons revealed no significant differences at baseline (p = 0.9563) or at 15 days (p = 0.7617); however, significant differences were detected between groups at 30 days (p = 0.0391) and 60 days (p = 0.0005). The single-drill group exhibited higher initial OPG levels, while the sequential-drill group had elevated OPG levels at 30 and 60 days.

Conclusion

The single-drill technique may provide an early advantage in osteoblastic response, while the sequential-drill technique supports increased osteoblastic activity at later stages. Both techniques effectively support osseointegration, with selection depending on specific clinical requirements.

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钻向成功：利用骨保护素水平对单钻和顺序钻技术进行牙种植体骨整合的比较研究-一项随机对照试验

以骨保护素（OPG）水平作为生物标志物，评估和比较单钻和顺序钻种植体部位制备技术的成骨细胞活性和骨整合。方法采用裂口设计的随机对照试验，纳入12名受试者（24颗种植体）。该研究包括两组：单次钻探组和连续钻探组。龈沟液分别于种植后15、30、60天采集。采用酶联免疫吸附试验（ELISA）测定骨保护素水平。结果单组分析显示OPG水平随时间变化显著(p <；0.0001)。组间比较显示基线时（p = 0.9563）或15天时（p = 0.7617）无显著差异；然而，在第30天（p = 0.0391）和第60天（p = 0.0005）组之间检测到显著差异。单钻组表现出较高的初始OPG水平，而连续钻组在30和60天的OPG水平升高。结论单次钻孔技术可能在成骨细胞反应中提供早期优势，而连续钻孔技术支持后期成骨细胞活性的增加。这两种技术都有效地支持骨整合，选择取决于具体的临床要求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.