Surgical Treatment of Peri‐Implantitis Combined With Keratinized Mucosa Augmentation: Results of a Dual‐Center 3‐Year RCT

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research Pub Date : 2025-06-21 DOI:10.1111/clr.14465

Myroslav Solonko, Erik Regidor, Alberto Ortiz‐Vigón, Eduardo Montero, Blanca Vilchez, Mariano Sanz

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Abstract

AimTo evaluate the medium‐term efficacy of using a xenogeneic collagen matrix to augment the width of the peri‐implant keratinized mucosa (PIKM) as an adjunct to the surgical treatment of peri‐implantitis.Material and MethodsIn this 36‐month parallel‐arm randomized controlled clinical trial, patients with peri‐implantitis were randomly assigned to a combined protocol of resective peri‐implantitis surgery and a PIKM augmentation procedure, either with an autologous free gingival graft (FGG) or a collagen matrix (CM). Primary outcomes were the increase in the width of PIKM and probing pocket depth (PPD) reduction at 36 months. As secondary outcomes, radiographic and patient‐reported outcomes were assessed.ResultsForty‐one patients (20 in the CM group and 21 in the FGG group) completed the three‐year follow‐up. PIKM increased in both groups, but the increase was significantly higher in the APF (apically positioned flap) + FGG group compared to the APF + CM group [2.0 (95% CI: 1.3, 2.7) mm in the FGG group compared to 1.0 (95% CI: 0.5, 1.5) mm in the CM group; p = 0.048]. PPDs were reduced by 1.5 mm (95% CI: 1.1, 1.9) and 1.4 mm (95% CI: 0.6, 2.2), respectively. Disease resolution (maximum one site with bleeding on probing, no suppuration, no further bone loss > 0.5 mm, and PD ≤ 5 mm) was 47.6% in the FGG group and 35.0% in the CM group.ConclusionTested surgical modalities resulted in similar improvements in the clinical parameters. Both FGG and CM increased the PIKM, but PIKM was greater at the 36‐month examination in the FGG group.

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种植体周围炎合并角化粘膜增强术的手术治疗：一项双中心3年随机对照研究的结果

目的评价异种胶原基质增加种植体周围角化粘膜（PIKM）宽度作为种植体周围炎手术治疗辅助手段的中期疗效。材料和方法在这项为期36个月的平行随机对照临床试验中，种植周炎患者被随机分配到一组联合方案，分别是自体游离牙龈移植物（FGG）或胶原基质（CM）。主要结果是36个月时PIKM宽度增加和探查袋深度（PPD）减少。作为次要结局，我们评估了影像学和患者报告的结局。结果41例患者（CM组20例，FGG组21例）完成了3年的随访。两组PIKM均增加，但APF（根尖定位皮瓣）+ FGG组比APF + CM组增加明显更高[FGG组为2.0 (95% CI: 1.3, 2.7) mm，而CM组为1.0 (95% CI: 0.5, 1.5) mm；P = 0.048]。ppd分别减少1.5 mm （95% CI: 1.1, 1.9）和1.4 mm （95% CI: 0.6, 2.2）。疾病解决（最多一个部位有探探出血，无化脓，无进一步骨质流失）；0.5 mm, PD≤5 mm)， FGG组为47.6%，CM组为35.0%。结论经过测试的手术方式在临床参数上有相似的改善。FGG和CM均增加PIKM，但FGG组在36个月检查时PIKM更高。

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来源期刊

Clinical Oral Implants Research 医学-工程：生物医学

CiteScore

7.70

自引率

11.60%

发文量

149

审稿时长

3 months

期刊介绍： Clinical Oral Implants Research conveys scientific progress in the field of implant dentistry and its related areas to clinicians, teachers and researchers concerned with the application of this information for the benefit of patients in need of oral implants. The journal addresses itself to clinicians, general practitioners, periodontists, oral and maxillofacial surgeons and prosthodontists, as well as to teachers, academicians and scholars involved in the education of professionals and in the scientific promotion of the field of implant dentistry.