Synergistic Defect-Driven Chemocatalysis and Ultrasound-Activated Piezocatalysis by Two-Dimensional SnSe Nanosheets

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2025-06-20 DOI:10.1021/acs.nanolett.4c06494

Chenglong Chen, Juan Wang, Jiuhui Xu, Qianyu Shi, Hao-Cheng Thong, Yi-Xuan Liu, Han Yu, Xinyue Zhang, Chao Li, Qian Li, Shun Li, Wen Gong, Xin Ma, Chang Su, Yige Xie, Fang-Zhou Yao, Ke Wang, Shujun Zhang, Shidong Wang

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引用次数: 0

Abstract

Osteosarcoma (OS) constitutes a severe malignant disorder affecting bone tissue and poses a significant global public health risk. Here, we introduce an injectable, synergistic chemopiezodynamic therapy utilizing tin selenide (SnSe) two-dimensional nanosheets, which generate reactive oxygen species (ROS) to target OS effectively. We observed clear antitumor effects in OS following treatment with SnSe. These effects are primarily attributed to Sn/Se vacancy-driven free radical catalysis, known as chemodynamic therapy, and are further augmented by ultrasonic vibrations for ultrasound-triggered piezocatalysis (piezodynamic therapy). Additionally, SnSe induced apoptosis and autophagy in OS cells while demonstrating satisfactory histocompatibility in mouse models. Comprehensive assessments at both in vitro cellular level and in vivo xenograft models confirm that injectable SnSe nanosheets achieve cytotoxicity and tumor eradication via the synergistic effects of chemo-piezocatalysis. This research paves the way for the customized development of advanced nanocatalysts with integrated synergistic catalysis, offering promising avenues for enhanced therapeutic strategies in oncology.

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二维SnSe纳米片协同缺陷驱动的化学催化和超声激活的压电催化

骨肉瘤（OS）是一种影响骨组织的严重恶性疾病，对全球公共卫生构成重大风险。在这里，我们介绍了一种可注射的、协同的化学动力学疗法，利用硒化锡（SnSe）二维纳米片，产生活性氧（ROS）来有效地靶向OS。我们观察到SnSe治疗OS后明显的抗肿瘤作用。这些效应主要归因于Sn/Se空位驱动的自由基催化，称为化学动力疗法，并通过超声波振动进一步增强超声波触发的压电催化（压电动力疗法）。此外，SnSe诱导OS细胞凋亡和自噬，同时在小鼠模型中表现出令人满意的组织相容性。体外细胞水平和体内异种移植模型的综合评估证实，可注射的SnSe纳米片通过化学压电催化的协同作用实现细胞毒性和肿瘤根除。本研究为集成协同催化的先进纳米催化剂的定制开发铺平了道路，为增强肿瘤治疗策略提供了有希望的途径。

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.