Current Trends in the Management of Recurrent Nasopharyngeal Carcinoma.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-06-20 DOI:10.1002/hed.28219

Vivek C Pandrangi, Jay J Liao, John R de Almeida, Ivan H El-Sayed, Glenn Hanna, Shirley Y Su, Raymond Tsang, Tae-Bin Won, Ian Witterick, Garret Choby, Edward C Kuan, Mathew Geltzeiler

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引用次数: 0

Abstract

Background: Recurrent nasopharyngeal carcinoma (NPC) is associated with challenges in treatment due to the complex anatomic location and impact of prior treatment modalities such as radiation therapy. The purpose of this review is to discuss modern treatment strategies for recurrent NPC, potential challenges, and outcomes.

Methods: A narrative review was performed, evaluating management strategies of recurrent NPC, survival measures, and advancements in treatment considerations.

Results: Treatment options including radiation, surgery, and chemotherapy are discussed, including data on survival outcomes and treatment-related morbidity. We review additional considerations including advances in endoscopic surgery, operative management of the internal carotid artery (ICA), novel radiation and chemotherapy protocols, and the introduction of immune checkpoint inhibitors.

Conclusion: This review describes contemporary management strategies for recurrent NPC, highlighting evolving management strategies that may reduce treatment-associated morbidity and improve survival.

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鼻咽癌复发治疗的最新趋势。

背景：复发性鼻咽癌（NPC）由于其复杂的解剖位置和既往治疗方式（如放疗）的影响，在治疗方面具有挑战性。本综述的目的是讨论复发性鼻咽癌的现代治疗策略、潜在挑战和结果。方法：进行叙述性回顾，评估复发性鼻咽癌的管理策略，生存措施和治疗考虑的进展。结果：讨论了包括放疗、手术和化疗在内的治疗方案，包括生存结果和治疗相关发病率的数据。我们回顾了其他考虑因素，包括内窥镜手术的进展，颈内动脉（ICA）的手术管理，新的放疗和化疗方案，以及免疫检查点抑制剂的引入。结论：本综述描述了复发性鼻咽癌的当代治疗策略，强调了可能降低治疗相关发病率和提高生存率的不断发展的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.