{"title":"Severe adenovirus type 7 infection in children: Case series from a paediatric intensive care unit in South India.","authors":"Machinary Puthenpurayil Jayakrishnan, Madona Devassikutty Fiji, Thekkile Gangadharan Sindhu, Vellani Thamunni Ajithkumar, George Kalpana, Balakrishnan Ajitha","doi":"10.1177/00494755251351520","DOIUrl":null,"url":null,"abstract":"<p><p>Human adenovirus type 7 (HAdV-7) can cause severe, multisystem disease in children. Between November 2019 and February 2020, 28 children with confirmed HAdV-7 infection were admitted to our paediatric intensive care unit in South India. Most were under 5 years, and 86% required mechanical ventilation. Multisystem involvement included myocarditis (61%), CNS disease (32%), and haemophagocytosis (32%), with a high mortality rate (57%). Follow-up showed recurrent wheeze (33%) and bronchiectasis (16%) in survivors. This case series highlights the clinical characteristics, management strategies and outcome of a large HAdV-7 outbreak in a paediatric intensive care unit. Surveillance is essential to detect and prevent future adenovirus outbreaks in vulnerable paediatric populations.</p>","PeriodicalId":49415,"journal":{"name":"Tropical Doctor","volume":" ","pages":"494755251351520"},"PeriodicalIF":0.5000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tropical Doctor","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/00494755251351520","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0
Abstract
Human adenovirus type 7 (HAdV-7) can cause severe, multisystem disease in children. Between November 2019 and February 2020, 28 children with confirmed HAdV-7 infection were admitted to our paediatric intensive care unit in South India. Most were under 5 years, and 86% required mechanical ventilation. Multisystem involvement included myocarditis (61%), CNS disease (32%), and haemophagocytosis (32%), with a high mortality rate (57%). Follow-up showed recurrent wheeze (33%) and bronchiectasis (16%) in survivors. This case series highlights the clinical characteristics, management strategies and outcome of a large HAdV-7 outbreak in a paediatric intensive care unit. Surveillance is essential to detect and prevent future adenovirus outbreaks in vulnerable paediatric populations.
期刊介绍：
The only journal written by and for health workers in low and middle-income countries, Tropical Doctor provides medical expertise and practical advice on how to apply current medical knowledge to the special circumstances of LMIC countries. This journal provides an ideal forum for sharing experiences and establishing best practice, aiding communication between medical professionals in different environments.
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