Is there a relationship between the route of HIV transmission and cognitive performance in older individuals living with HIV?

IF 3.2 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Archives of Public Health Pub Date : 2025-06-19 DOI:10.1186/s13690-025-01657-6

Francesco Salis, Maristella Belfiori, Francesco Ortu, Paola Piano, Stefano Del Giacco, Antonella Mandas

{"title":"Is there a relationship between the route of HIV transmission and cognitive performance in older individuals living with HIV?","authors":"Francesco Salis, Maristella Belfiori, Francesco Ortu, Paola Piano, Stefano Del Giacco, Antonella Mandas","doi":"10.1186/s13690-025-01657-6","DOIUrl":null,"url":null,"abstract":"Background: - HIV-related neurocognitive disorders are a growing public health issue, especially in older people living with HIV/AIDS (PLWHA). The aim of this study is to evaluate the relationship between cognitive performance and route of HIV transmission in an older group of PLWHA.Methods: - In this cross-sectional study, conducted between November 2022 and July 2023, we enrolled PLWHA aged 50 years or older, treated with highly active anti-retroviral therapy, and with a low/undetectable viral load. Cognitive assessment was performed with HIV Dementia Scale.Results: In total, 268 subjects were enrolled. Cognitive impairment was present in 20.9% of the participants. According to a logistic model, people who contracted HIV through sexual transmission had 74% lower odds of cognitive impairment compared to those who contracted HIV through intravenous substance use (OR: 0.26, 95%CI 0.12-0.56). The adjustment for confounders confirmed lower odds for sexual transmission (OR: 0.27, 95%CI 0.12-0.60).Conclusions: The route of HIV transmission is potentially associated with cognitive impairment in PLWHA, with patients infected via intravenous substance use being at higher risk.","PeriodicalId":48578,"journal":{"name":"Archives of Public Health","volume":"83 1","pages":"161"},"PeriodicalIF":3.2000,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178064/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Public Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13690-025-01657-6","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}

引用次数: 0

Abstract

Background: - HIV-related neurocognitive disorders are a growing public health issue, especially in older people living with HIV/AIDS (PLWHA). The aim of this study is to evaluate the relationship between cognitive performance and route of HIV transmission in an older group of PLWHA.

Methods: - In this cross-sectional study, conducted between November 2022 and July 2023, we enrolled PLWHA aged 50 years or older, treated with highly active anti-retroviral therapy, and with a low/undetectable viral load. Cognitive assessment was performed with HIV Dementia Scale.

Results: In total, 268 subjects were enrolled. Cognitive impairment was present in 20.9% of the participants. According to a logistic model, people who contracted HIV through sexual transmission had 74% lower odds of cognitive impairment compared to those who contracted HIV through intravenous substance use (OR: 0.26, 95%CI 0.12-0.56). The adjustment for confounders confirmed lower odds for sexual transmission (OR: 0.27, 95%CI 0.12-0.60).

Conclusions: The route of HIV transmission is potentially associated with cognitive impairment in PLWHA, with patients infected via intravenous substance use being at higher risk.

Abstract Image

查看原文本刊更多论文

老年艾滋病毒感染者的艾滋病毒传播途径与认知能力之间是否存在关系？

背景：-艾滋病毒相关的神经认知障碍是一个日益严重的公共卫生问题，特别是在老年艾滋病毒/艾滋病患者（PLWHA）中。本研究的目的是评估老年艾滋病感染者的认知能力与艾滋病毒传播途径之间的关系。方法：在2022年11月至2023年7月期间进行的这项横断面研究中，我们招募了50岁或以上的感染者，接受高活性抗逆转录病毒治疗，病毒载量低/无法检测。认知能力评估采用HIV痴呆量表。结果：共纳入268名受试者。20.9%的参与者存在认知障碍。根据逻辑模型，通过性传播感染艾滋病毒的人与通过静脉注射药物感染艾滋病毒的人相比，认知障碍的几率低74% （OR: 0.26, 95%CI 0.12-0.56）。校正混杂因素证实性传播的几率较低（OR: 0.27, 95%CI 0.12-0.60）。结论：艾滋病毒的传播途径可能与艾滋病患者的认知障碍有关，通过静脉注射药物感染的患者风险更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Archives of Public Health Medicine-Public Health, Environmental and Occupational Health

CiteScore

4.80

自引率

3.00%

发文量

244

审稿时长

16 weeks

期刊介绍： rchives of Public Health is a broad scope public health journal, dedicated to publishing all sound science in the field of public health. The journal aims to better the understanding of the health of populations. The journal contributes to public health knowledge, enhances the interaction between research, policy and practice and stimulates public health monitoring and indicator development. The journal considers submissions on health outcomes and their determinants, with clear statements about the public health and policy implications. Archives of Public Health welcomes methodological papers (e.g., on study design and bias), papers on health services research, health economics, community interventions, and epidemiological studies dealing with international comparisons, the determinants of inequality in health, and the environmental, behavioural, social, demographic and occupational correlates of health and diseases.