Tanzanian gut microbiota profiles linked to high but rapidly waning yellow fever antibody titers.

IF 7.8 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2025-06-19 DOI:10.1038/s41522-025-00687-w

Jeremia J Pyuza, Marloes M A R van Dorst, David Barnett, Koen Stam, Mikhael Manurung, Linda Wammes, Marion König, Yvonne Kruize, Nikuntufya Andongolile, Anastazia Ngowi, Elichilia R Shao, Vesla I Kullaya, Alex Mremi, Pancras C W Hogendoorn, Sia E Msuya, Simon P Jochems, John Penders, Maria Yazdanbakhsh, Wouter A A de Steenhuijsen Piters

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Abstract

Vaccine responses vary across populations and are influenced by numerous intrinsic and extrinsic factors, including the gut microbiota. However, studies linking microbiota composition to vaccine immunogenicity in low- and middle-income countries are sparse. In this study, we examined the gut microbiota of 143 healthy rural and urban living Tanzanians who participated in a yellow fever vaccine (YF-17D) trial. We found significant differences in gut microbiota profiles between rural and urban participants. Rural-associated microbiota showed higher diversity and enrichment of taxa like Prevotella and Succinivibrio, which were linked to dietary intake patterns. Yellow fever neutralizing antibody titers were higher in rural compared to urban participants. Interestingly, a subset of urban individuals with a rural-like microbiota had higher antibody titers and faster antibody waning than those with a more industrialized microbiota. These findings suggest that gut microbiota composition might be linked to vaccine immunogenicity, potentially outweighing the influence of living location.

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坦桑尼亚的肠道微生物群与黄热病抗体滴度高但迅速下降有关。

疫苗反应因人群而异，并受到许多内在和外在因素的影响，包括肠道微生物群。然而，在低收入和中等收入国家，将微生物群组成与疫苗免疫原性联系起来的研究很少。在这项研究中，我们检查了143名参加黄热病疫苗（YF-17D）试验的健康坦桑尼亚农村和城市居民的肠道微生物群。我们发现农村和城市参与者的肠道菌群特征存在显著差异。农村相关微生物群显示出更高的多样性和丰富性，如普雷沃氏菌和琥珀酸弧菌，这与饮食摄入模式有关。与城市参与者相比，农村的黄热病中和抗体滴度更高。有趣的是，与那些具有工业化微生物群的人相比，具有农村样微生物群的城市个体的一小部分具有更高的抗体滴度和更快的抗体衰减速度。这些发现表明，肠道菌群组成可能与疫苗免疫原性有关，可能超过生活地点的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.