The effect of breastfeeding on treatment outcomes in in-vitro fertilization frozen embryo transfer cycles.

IF 2.7 3区医学 Q2 GENETICS & HEREDITY

Journal of Assisted Reproduction and Genetics Pub Date : 2025-06-20 DOI:10.1007/s10815-025-03556-9

Alyssa Hochberg, Nir Kugelman, Uri Amikam, Victoria Bleau, Tzippy Shochat, Eva Suarthana, William Buckett

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引用次数: 0

Abstract

Purpose: While breastfeeding is known to impact unassisted conception, its effect on fertility treatment outcomes remains unclear. This study aimed to evaluate the effect of breastfeeding on in-vitro fertilization (IVF) frozen embryo transfer (FET) outcomes.

Methods: A retrospective cohort study at a single, urban, Canadian Fertility center, including women who underwent an FET(2015-2023). Breastfeeding women (study group) were compared to non-breastfeeding controls, matched 1:1 for age, treatment protocol, and year. We compared outcomes between the two groups. Primary outcomes were pregnancy rate (PR), clinical pregnancy rate (CPR),and live birth rate (LBR). Secondary outcomes included peak endometrial thickness prior to progesterone supplementation, biochemical PR and miscarriage rate. Multivariate logistic regression controlled for confounders. Two sub-analyses within the breastfeeding group examined treatment outcomes by breastfeeding duration (≤ 12 months; > 12 months) and prolactin levels (normal;elevated).

Results: Overall, 118 women met inclusion criteria (59 breastfeeding, 59 controls). Breastfeeding women, compared to controls,were characterized by a younger median age at initial oocyte collection (34.8 years(31.9-37.11) vs. 35.85 years(33.2-39.2),p = 0.044); higher median parity (1(1-1) vs. 0(0-1), p < 0.0001);and higher rates of irregular cycles (35.59% vs. 18.64%,p = 0.016);and elevated prolactin levels (16.95% vs. 1.69%,p = 0.003). Utilizing multivariate logistic regression adjusting for breastfeeding status,parity, age at initial oocyte collection, and cycle regularity, only maternal age at oocyte collection was associated with PR (adjusted odds ratio 0.84, 95% confidence interval 0.75-0.94,p = 0.003). Both sub-analyses revealed similar PRs, CPRs and LBRs between groups.

Conclusions: Breastfeeding during an FET cycle was not associated with treatment outcomes, including PR,CPR, or LBR, providing cautious reassurance to physicians and patients.

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母乳喂养对体外受精冷冻胚胎移植周期治疗结果的影响。

目的：虽然已知母乳喂养会影响无辅助受孕，但其对生育治疗结果的影响尚不清楚。本研究旨在评估母乳喂养对体外受精（IVF）冷冻胚胎移植（FET）结果的影响。方法：在加拿大一个城市生育中心进行回顾性队列研究，包括接受FET的妇女（2015-2023）。将母乳喂养的妇女（研究组）与非母乳喂养的对照组进行比较，年龄、治疗方案和年龄的比例为1:1。我们比较了两组的结果。主要结局为妊娠率（PR）、临床妊娠率（CPR）和活产率（LBR）。次要结局包括补充黄体酮前子宫内膜峰值厚度、生化PR和流产率。多元逻辑回归控制混杂因素。母乳喂养组的两个亚分析通过母乳喂养持续时间（≤12个月；0 ~ 12个月）和催乳素水平（正常；升高）来检查治疗结果。结果：总体而言，118名妇女符合纳入标准（59名母乳喂养，59名对照组）。与对照组相比，母乳喂养妇女的特征是初始卵母细胞收集的中位年龄更年轻（34.8岁（33.9 -37.11）对35.85岁（33.2-39.2），p = 0.044）；结论：在FET周期中母乳喂养与包括PR、CPR或LBR在内的治疗结果无关，为医生和患者提供了谨慎的保证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Assisted Reproduction and Genetics 医学-妇产科学

CiteScore

5.70

自引率

9.70%

发文量

286

审稿时长

1 months

期刊介绍： The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.