{"title":"A retrospective report on xenotransfusion of canine serum albumin in five critically ill cats.","authors":"Eric Sirabian, Rebecca A Walton, April E Blong","doi":"10.3389/fvets.2025.1585988","DOIUrl":null,"url":null,"abstract":"<p><p>This retrospective case series describes the xenotransfusion of canine serum albumin (CSA) in five critically ill cats. Four cats received a single xenotransfusion of CSA, while one cat received two separate xenotransfusions. Overall, two out of five cats (40%) survived long enough to be discharged, which is similar to previously published survival rates for critically ill cats. One cat exhibited clinical signs attributable to acute transfusion-associated circulatory overload (TACO), while two cats showed clinical signs suggestive of a possible, although less likely, transfusion reaction. While a prospective study is needed, the review of the cases presented here suggests that CSA may provide oncotic and hemodynamic support and be safe to administer to critically ill cats.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1585988"},"PeriodicalIF":2.6000,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177886/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Veterinary Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fvets.2025.1585988","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
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Abstract
This retrospective case series describes the xenotransfusion of canine serum albumin (CSA) in five critically ill cats. Four cats received a single xenotransfusion of CSA, while one cat received two separate xenotransfusions. Overall, two out of five cats (40%) survived long enough to be discharged, which is similar to previously published survival rates for critically ill cats. One cat exhibited clinical signs attributable to acute transfusion-associated circulatory overload (TACO), while two cats showed clinical signs suggestive of a possible, although less likely, transfusion reaction. While a prospective study is needed, the review of the cases presented here suggests that CSA may provide oncotic and hemodynamic support and be safe to administer to critically ill cats.
期刊介绍：
Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy.
Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field.
Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.
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