Preston R Steele, Joel Feldmann, Katharina A Quinlan, Marin Manuel
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引用次数: 0
Abstract
Background: Movement disorders such as cerebral palsy (CP) are frequently associated with joint and muscle stiffness, often evaluated using subjective clinical methods like the Modified Ashworth Scale or Tardieu Scale. These approaches lack precision and reproducibility, particularly in preclinical models, limiting their utility in translational research.
Methods: This study presents the development of a low-cost, open-source torquemeter device tailored for use in a neonatal rabbit model of CP. The device is designed to quantify joint stiffness objectively by measuring torque across a range of controlled joint rotation speeds, a key factor in evaluating hypertonia associated with spasticity and dystonia. The construction process is straightforward, with all components being either commercially available or 3D-printable and requiring only basic assembly tools.
Results: The torquemeter demonstrated precise, reproducible measurements of torque and joint stiffness in pilot studies, validating its applicability in preclinical settings. By eliminating subjective biases, the device provides robust data to assess the effectiveness of therapeutic interventions targeting spasticity.
Conclusion: This low-cost torquemeter offers an accessible, reliable tool for preclinical movement disorder research. Its ability to quantify limb stiffness with high precision enhances the evaluation of treatment strategies in CP models, paving the way for improved therapeutic development and outcomes.
期刊介绍：
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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