Metabolite Profiles in Response to Dietary Interventions for Management of Blood Pressure: A Systematic Review.

IF 4.6 3区医学 Q1 NUTRITION & DIETETICS

Current Nutrition Reports Pub Date : 2025-06-20 DOI:10.1007/s13668-025-00676-7

María Gómez-Martín, Floor Rikken, Erin D Clarke, Jordan Stanford, Jessica J A Ferguson, Clare E Collins

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引用次数: 0

Abstract

Background: Hypertension is a major global public health issue. The mechanisms through which diet influences blood pressure (BP) remain to be fully elucidated. Nutritional metabolomics offers an objective method for examining diet-health outcomes, including the contribution of intermediate molecules and metabolic byproducts or metabolites to BP regulation. To date, no review has investigated the relationship between diet, metabolites and BP regulation.

Objective: This systematic review aim was to synthesise findings of human dietary intervention studies on BP, including feeding studies providing all foods and meals, as well as those that provided supplements.

Methods: Six databases were systematically searched (Scopus, Medline, Embase, CINAHL, PsycINFO, and Cochrane) for intervention studies examining the relationship between dietary metabolites and BP regulation. The Academy of Nutrition and Dietetics Quality Criteria were used to assess the risk of bias.

Results: Twelve articles (11 unique studies) met the inclusion criteria, reporting 11 significant associations between metabolites and BP, while one study found no significant associations. More than 100 metabolites were associated with BP, 40 associated with SBP, 29 with DBP, 31 with both, and 2 did not differentiate between SBP or DBP. Only two metabolites, proline-betaine and N-acetylneuraminate, had significant relationships with BP measurement in more than one study.

Conclusions: This review identified a shortlist of potential metabolite indicators of response to dietary interventions for BP regulation. Findings highlight nutritional metabolomics as a potential contributor to understanding diet-induced changes in BP and CVD risk reduction. However, variability in reported metabolites and limited replication across studies may affect specificity and limit generalizability. Further research is needed to better understand this relationship.

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代谢谱对饮食干预血压管理的响应：一项系统综述。

背景：高血压是一个重大的全球公共卫生问题。饮食影响血压（BP）的机制仍有待充分阐明。营养代谢组学为检查饮食健康结果提供了一种客观的方法，包括中间分子和代谢副产物或代谢物对血压调节的贡献。到目前为止，还没有研究饮食、代谢物和血压调节之间关系的综述。目的：本系统综述的目的是综合人类饮食干预对BP的研究结果，包括提供所有食物和膳食的喂养研究，以及提供补充剂的研究。方法：系统检索6个数据库（Scopus, Medline, Embase， CINAHL， PsycINFO和Cochrane），研究饮食代谢物与血压调节之间关系的干预研究。采用美国营养与饮食学会质量标准评估偏倚风险。结果：12篇文章（11项独特的研究）符合纳入标准，报告了11项代谢物与BP之间的显著相关性，1项研究未发现显著相关性。超过100种代谢物与血压相关，40种与收缩压相关，29种与舒张压相关，31种与舒张压和收缩压都相关，2种不区分舒张压和舒张压。在不止一项研究中，只有脯氨酸-甜菜碱和n -乙酰神经胺酸两种代谢物与血压测量有显著关系。结论：本综述确定了饮食干预对血压调节反应的潜在代谢物指标。研究结果强调，营养代谢组学可能有助于理解饮食引起的血压和心血管疾病风险降低的变化。然而，代谢物报告的可变性和研究间有限的重复性可能会影响特异性和限制普遍性。需要进一步的研究来更好地理解这种关系。

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来源期刊

Current Nutrition Reports Agricultural and Biological Sciences-Food Science

CiteScore

7.70

自引率

2.00%

发文量

期刊介绍： This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.