Emotional distress and assisted reproductive technology outcomes among women with unexplained infertility: a nested case-control study.

IF 3.2 3区医学 Q2 PSYCHIATRY

Archives of Women's Mental Health Pub Date : 2025-06-19 DOI:10.1007/s00737-025-01597-8

Jiwei Sun, Bing Sun, Xiaofei Sun, Yuzhi Duan, Jingmei Hu, Kuona Hu, Xiulei Zhang, Linlin Cui, Zi-Jiang Chen

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引用次数: 0

Abstract

Objectives: Identifying the specific etiology of unexplained infertility is a focus of reproductive research, particularly investigating overlooked topics such as addressing the emotional and psychological impact of infertility. The present study aimed to explore the association between emotional distress (anxiety and depression) and assisted reproductive technology outcomes among women with unexplained infertility in a nested case-control study.

Methods: Each woman with unexplained infertility and assisted reproductive technology failure (case group) was matched by age and body mass index (BMI) with one randomly selected woman with unexplained infertility and successful assisted reproductive technology (control group). Totally, 1512 patients in case group and 1512 matched controls were identified.

Results: Anxiety and depression in women with unexplained infertility were associated with a significant increased risk of failed assisted reproductive technology, respectively. The Johnson-Neyman plot for the conditional effect of anxiety symptoms indicated that the negative impact on assisted reproductive technology outcomes depended on the pre-pregnancy BMI (22.796-30.914 kg/m²), whereas the effect of depression symptoms on assisted reproductive technology outcomes depended on both age (27.749-39.048 years) and pre-pregnancy BMI (19.514-28.389 kg/m²).

Conclusions: Monitoring emotional distress among women of reproductive age or those who are not obese and have unexplained infertility is crucial.

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不明原因不孕症妇女的情绪困扰和辅助生殖技术结果：一项巢式病例对照研究。

目的：确定不明原因不孕症的具体病因是生殖研究的重点，特别是调查被忽视的主题，如解决不孕症的情绪和心理影响。本研究旨在通过巢式病例对照研究，探讨不明原因不孕症妇女的情绪困扰（焦虑和抑郁）与辅助生殖技术结果之间的关系。方法：将1例不明原因不孕并辅助生殖技术失败的女性（病例组）与随机选择1例不明原因不孕并辅助生殖技术成功的女性（对照组）按年龄和体重指数（BMI）进行匹配。病例组1512例，对照组1512例。结果：不明原因不孕妇女的焦虑和抑郁分别与辅助生殖技术失败的风险显著增加相关。焦虑症状条件效应的Johnson-Neyman图显示，焦虑症状对辅助生殖技术结果的负面影响取决于孕前BMI (22.796 ~ 30.914 kg/m2)，而抑郁症状对辅助生殖技术结果的影响取决于年龄（27.749 ~ 39.048岁）和孕前BMI （19.514 ~ 28.389 kg/m2）。结论：监测育龄妇女或那些不肥胖但有不明原因不孕的妇女的情绪困扰是至关重要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Women's Mental Health 医学-精神病学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Archives of Women’s Mental Health is the official journal of the International Association for Women''s Mental Health, Marcé Society and the North American Society for Psychosocial Obstetrics and Gynecology (NASPOG). The exchange of knowledge between psychiatrists and obstetrician-gynecologists is one of the major aims of the journal. Its international scope includes psychodynamics, social and biological aspects of all psychiatric and psychosomatic disorders in women. The editors especially welcome interdisciplinary studies, focussing on the interface between psychiatry, psychosomatics, obstetrics and gynecology. Archives of Women’s Mental Health publishes rigorously reviewed research papers, short communications, case reports, review articles, invited editorials, historical perspectives, book reviews, letters to the editor, as well as conference abstracts. Only contributions written in English will be accepted. The journal assists clinicians, teachers and researchers to incorporate knowledge of all aspects of women’s mental health into current and future clinical care and research.