N,N'-Bis(4-Bromo-2-hydroxybenzylidene)ethylenediamine and Its Copper(II), Zinc(II) and Cobalt(III) Complexes: Synthesis, Crystal Structures and Urease Inhibition.

IF 1.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Rundong Lu, Jinkai Lei, Jiacheng Liu, Chi Liu, Liuxiu Chen, Wu Chen
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引用次数: 0

Abstract

A new Schiff base compound N,N'-bis(4-bromo-2-hydroxybenzylidene)ethylenediamine (H2L) was prepared by reaction of 4-bromosalicylaldehyde with ethane-1,2-diamine in methanol. Reaction of H2L with copper acetate and zinc acetate in methanol, respectively, afforded two mononuclear complexes [CuL] (1) and [ZnL(OH2)] (2). Reaction of H2L with cobalt nitrate in the presence of ammonium thiocyanate in a mixture of methanol and DMF afforded a mononuclear cobalt(III) complex [CoL(NCS)(OH2)]·DMF (3). The free Schiff base and the complexes were characterized by elemental analysis and infrared spectra, as well as single crystal X-ray determination. 1H NMR spectrum was also performed for H2L. The deprotonated form of the Schiff base coordinates to the metal atoms through all the phenolate oxygen and imino nitrogen atoms. The Cu(II) atom in complex 1 is in square planar coordination. The Zn(II) atom in complex 2 is in square pyramidal coordination. The Co(III) atom in complex 3 is in octahedral coordination. The urease inhibitory assay reveals that the copper(II) complex has the most effective activity.

N,N'-双(4-溴-2-羟基苄基)乙二胺及其铜(II)、锌(II)和钴(III)配合物:合成、晶体结构和脲酶抑制作用
以4-溴水杨醛与乙烷-1,2-二胺为原料,在甲醇中合成了新的希夫碱化合物N,N'-双(4-溴-2-羟基苄基)乙二胺。H2L分别与乙酸铜和乙酸锌在甲醇中反应,得到两个单核配合物[CuL](1)和[ZnL(OH2)](2)。在硫氰酸铵存在下,H2L与硝酸钴在甲醇和DMF的混合物中反应,得到单核钴(III)配合物[CoL(NCS)(OH2)]·DMF(3)。通过元素分析、红外光谱和单晶x射线测定对游离希夫碱及其配合物进行了表征。对H2L进行了1H NMR谱分析。希夫碱的去质子化形式通过所有的酚氧和亚氨基氮原子与金属原子作坐标。配合物1中的Cu(II)原子呈平面方配位。配合物2中的Zn(II)原子呈方锥体配位。配合物3中的Co(III)原子呈八面体配位。脲酶抑制实验表明,铜(II)配合物具有最有效的活性。
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来源期刊
Acta Chimica Slovenica
Acta Chimica Slovenica 化学-化学综合
CiteScore
2.50
自引率
25.00%
发文量
80
审稿时长
1.0 months
期刊介绍: Is an international, peer-reviewed and Open Access journal. It provides a forum for the publication of original scientific research in all fields of chemistry and closely related areas. Reviews, feature, scientific and technical articles, and short communications are welcome.
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