Unravelling the self-assembly of a novel cationic pseudo-gemini surfactant and its monomeric counterpart: interactions with DNA and BSA in aqueous medium at neutral pH.

IF 2.9 3区 化学 Q3 CHEMISTRY, PHYSICAL
Soft Matter Pub Date : 2025-06-20 DOI:10.1039/d5sm00075k
Homen Dahal, Sachin Soren, Shashi Kumar, Joykrishna Dey
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引用次数: 0

Abstract

The demand for sustainable, efficient, and easily tunable cationic surfactants is growing rapidly due to their pivotal role in gene therapy, drug delivery, and biotechnology. However, conventional gemini surfactants often require laborious synthesis and lack design flexibility. Here, we introduce a novel pseudo-gemini surfactant system, innovatively constructed through simple non-covalent electrostatic interactions between a hydrophobic tertiary amine and a dibasic acid. This minimalist design approach bypasses traditional synthetic complexity, offering a rapid, modular pathway to functional surfactants. Our findings demonstrate that this new surfactant not only self-assembles into thermodynamically stable structures but also exhibits superior binding affinity to key biomacromolecules like DNA and BSA, as validated by spectroscopy and docking studies. The strong and specific interactions underscore its potential for high-impact applications in biomedicine. This work redefines the design paradigm for cationic surfactants and addresses an urgent need for accessible yet high-performance agents in therapeutic and industrial settings.

揭开一种新型阳离子伪gemini表面活性剂及其单体对应物的自组装:在中性pH水溶液中与DNA和牛血清白蛋白的相互作用。
由于阳离子表面活性剂在基因治疗、药物传递和生物技术中的关键作用,对可持续、高效和易于调节的阳离子表面活性剂的需求正在迅速增长。然而,传统的双子星表面活性剂往往需要费力的合成和缺乏设计灵活性。在这里,我们介绍了一种新的伪gemini表面活性剂体系,创新地通过疏水叔胺和二酸之间的简单非共价静电相互作用构建。这种极简的设计方法绕过了传统合成的复杂性,为功能性表面活性剂提供了快速、模块化的途径。我们的研究结果表明,这种新的表面活性剂不仅可以自组装成热力学稳定的结构,而且对DNA和BSA等关键生物大分子具有优越的结合亲和力,这一点得到了光谱和对接研究的证实。这种强而特异的相互作用强调了其在生物医学中具有高影响力应用的潜力。这项工作重新定义了阳离子表面活性剂的设计范式,并解决了治疗和工业环境中可获得的高性能试剂的迫切需求。
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来源期刊
Soft Matter
Soft Matter 工程技术-材料科学:综合
CiteScore
6.00
自引率
5.90%
发文量
891
审稿时长
1.9 months
期刊介绍: Soft Matter is an international journal published by the Royal Society of Chemistry using Engineering-Materials Science: A Synthesis as its research focus. It publishes original research articles, review articles, and synthesis articles related to this field, reporting the latest discoveries in the relevant theoretical, practical, and applied disciplines in a timely manner, and aims to promote the rapid exchange of scientific information in this subject area. The journal is an open access journal. The journal is an open access journal and has not been placed on the alert list in the last three years.
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