Folate-Modified Drug-Carrying Micelles With pH-Responsiveness for Curcumin-Targeted Delivery

IF 2.7 3区化学 Q2 POLYMER SCIENCE

Journal of Applied Polymer Science Pub Date : 2025-04-22 DOI:10.1002/app.57180

Xiuhong Duan, Zimeng Wang, Handa Liu, Hua Ma, Xuepeng Zhang, Lihua Liu, Hongzhou Shang, Ning Qiao

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引用次数: 0

Abstract

A predrug delivery system combining tumor-targeting and pH-responsive features was synthesized using baicalin (BAI), polyethylene glycol (PEG), and folic acid (FA). BAI and PEG were linked via esterification to create pH-sensitive ester bonds (COO) that facilitate drug release in acidic environments, while FA was attached to PEG through substitution. This system, named FA-PEG-COO-BAI (FPB), encapsulated curcumin (CUR) to form drug-loaded micelles. The impact of drug-loading conditions, such as sonication duration and initial drug dosage, on CUR/FA-PEG-COO-BAI encapsulation efficiency and drug release was investigated. In vitro studies demonstrated a maximum encapsulation rate of (73.09 ± 3.31)% and a drug-loading rate of (11.90 ± 0.69)%. Drug release from CUR/FA-PEG-COO-BAI micelles accelerated as pH decreased, confirming pH-responsive behavior. Cellular uptake and antitumor assays suggested effective tumor targeting and inhibition of proliferation. Hemolysis and cell viability assays indicated low toxicity. These findings underscore the potential of CUR/FA-PEG-COO-BAI micelles for controlled drug release and targeted therapy.

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具有ph响应性的叶酸修饰的载药胶束用于姜黄素靶向递送

以黄芩苷（BAI）、聚乙二醇（PEG）和叶酸（FA）为原料，合成了一种结合肿瘤靶向和ph响应特性的药物前递送系统。BAI和PEG通过酯化反应连接，形成ph敏感的酯键，促进药物在酸性环境中释放，而FA通过取代连接到PEG上。该系统被命名为FA-PEG-COO-BAI (FPB)，封装姜黄素（CUR）形成载药胶束。考察超声时间、初始给药剂量等载药条件对CUR/FA-PEG-COO-BAI包封效率和药物释放的影响。体外实验表明，其包封率为（73.09±3.31）%，载药率为（11.90±0.69）%。随着pH的降低，CUR/FA-PEG-COO-BAI胶束的药物释放加速，证实了pH响应行为。细胞摄取和抗肿瘤实验表明其有效靶向肿瘤和抑制增殖。溶血和细胞活力试验显示低毒性。这些发现强调了CUR/ fa - peg - co - bai胶束在控制药物释放和靶向治疗方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Applied Polymer Science 化学-高分子科学

CiteScore

5.70

自引率

10.00%

发文量

1280

审稿时长

2.7 months

期刊介绍： The Journal of Applied Polymer Science is the largest peer-reviewed publication in polymers, #3 by total citations, and features results with real-world impact on membranes, polysaccharides, and much more.