A magnetically actuated microcatheter with soft rotatable tip for enhanced endovascular access and treatment efficiency

IF 11.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-06-20 DOI:10.1126/sciadv.adv1682

Moqiu Zhang, Lidong Yang, Haojin Yang, Lin Su, Junnan Xue, Qinglong Wang, Bo Hao, Yihang Jiang, Kai Fung Chan, Joseph Jao Yiu Sung, Ho Ko, Xurui Liu, Liu Wang, Bonaventure Yiu Ming Ip, Thomas Wai Hong Leung, Li Zhang

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引用次数: 0

Abstract

Endovascular interventions require fast access to affected regions, followed by effective treatment. Catheterizations are effective approaches for treating vascular diseases; however, they face challenges in accessibility, efficiency, and invasiveness in narrow, tortuous vascular systems. This study presents a submillimeter magnetically actuated soft rotatable-tipped microcatheter (MSRM) designed to access small blood vessels and provide efficient, minimally invasive therapeutic interventions for blood clot treatment. The MSRM’s rotatable tip design enhances accessibility and navigation speed through a rotation-assisted active steering strategy. Improved blood clot treatment efficiency is achieved through the MSRM’s multifunctionality: It can accelerate drug-blood clot interactions, mechanically break down blood clots, and retrieve clot debris. The low invasiveness is attributed to the soft material design and conservative actuation strategy. The performance of the MSRM is validated in both in vitro phantom studies and in vivo rabbit models, and the invasiveness is evaluated using a human placenta model.

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一种具有软可旋转尖端的磁致微导管，用于增强血管内通路和治疗效率

血管内干预需要快速进入受影响的区域，然后进行有效的治疗。导管插入术是治疗血管疾病的有效方法；然而，它们在狭窄、弯曲的血管系统中的可及性、效率和侵入性方面面临挑战。本研究提出了一种亚毫米磁驱动软可旋转尖端微导管（MSRM），旨在进入小血管，并为血栓治疗提供有效的微创治疗干预。MSRM的可旋转尖端设计通过旋转辅助主动转向策略提高了可达性和导航速度。通过MSRM的多功能性，提高了血凝块的治疗效率：它可以加速药物-血凝块的相互作用，机械地分解血凝块，并回收血凝块碎片。其低侵入性主要归功于柔软的材料设计和保守的驱动策略。MSRM的性能在体外幻影研究和兔体内模型中都得到了验证，并使用人类胎盘模型评估了其侵入性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.