Genotyping of the gene polymorphisms FASL 844C/T and FAS 670A/G in patients with idiopathic infertility in Iraq.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI:10.1590/1806-9282.20241860

Abbas Ali Manshd, Mohammed Ali Alaboudi, Abbas Abdulameer Al-Raad

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Abstract

Objective: The failure to conceive following 12 months of unprotected intercourse is referred to as infertility. About 35% of the instances include women and 30% involve men.

Aim: The aim of this study was to investigate the gene polymorphisms FASL-844C/T and FAS-670A/G in the promoter region to evaluate susceptibility to male infertility.

Methods: We have investigated single-nucleotide polymorphisms of FAS-670A/G gene and FASL-844C/T gene in 100 subjects. A total of 50 male patients with infertility constituted the infertility group and another group consisting of 50 apparently healthy individuals comprised the control group.

Results: The prevalence rate of FAS-670A/G gene polymorphism was statistically significant among both azoospermia and oligospermia subgroups, the homozygous mutant genotype GG (p=0.014 and p=0.043), and mutant allele G (p=0.001 and p=0.004), respectively. Also, FASL-844C/T gene polymorphism was statistically significant among both azoospermia and oligospermia subgroups, the homozygous mutant genotype TT (p=0.032 and p=0.032), and mutant allele T (p=0.007 and p=0.002), respectively.

Conclusions: FAS homozygous mutant genotype (GG) and FASL homozygous mutant genotype (TT) act as etiologic factors in male infertility.

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伊拉克特发性不孕症患者FASL 844C/T和FAS 670A/G基因多态性的基因分型

目的：12个月无保护性交后不能怀孕被称为不孕症。大约35%的案例涉及女性，30%涉及男性。目的：研究启动子区FASL-844C/T和FAS-670A/G基因多态性，评价男性不育的易感性。方法：对100例受试者进行FAS-670A/G基因和FASL-844C/T基因单核苷酸多态性分析。男性不育症患者50例作为不育组，另一组由50例表面健康的个体组成为对照组。结果：FAS-670A/G基因多态性在无精子症和少精子症亚组、纯合突变基因型GG （p=0.014和p=0.043）和突变等位基因G （p=0.001和p=0.004）的患病率均有统计学意义。FASL-844C/T基因多态性在无精子症和少精子症亚组、纯合子突变基因型TT （p=0.032和p=0.032）和突变等位基因T （p=0.007和p=0.002）中均有统计学意义。结论：FAS纯合突变基因型（GG）和FASL纯合突变基因型（TT）是男性不育的病因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista da Associacao Medica Brasileira (1992)

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