The Biochemical Effects of Resveratrol Intake on the Neurobehavioral Aspects of Autism Spectrum Disorders: A Systematic Review.

Central nervous system agents in medicinal chemistry Pub Date : 2025-06-16 DOI:10.2174/0118715249387274250521054238

Masoud Nikfarjam, Saeid Heidari-Soureshjani, Sahar Rostamian, Karamali Kasiri

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Abstract

Introduction/objective: Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by various neurobehavioral impairments. This study aims to review the preventive and therapeutic effects of Resveratrol (RSV) against ASD during various stages of life, specifically focusing on its influence on behavioral and neurodevelopmental biochemical mechanisms.

Methods: On December 6, 2024, a comprehensive electronic search was conducted across several high-coverage databases, including Web of Science, Scopus, PubMed/MEDLINE, Embase, and the Cochrane Library. The most important data were extracted and reviewed after screening the publications based on our inclusion and exclusion criteria.

Results: RSV alleviates autistic-like social behaviors by promoting social interaction and mitigating repetitive behaviors, anxiety, and symptoms resembling depression. RSV influences chemokine receptor expression, diminishes pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interferon-gamma (IFN-γ), and regulates mitochondrial function by reducing nitrosative stress and thiobarbituric acid reactive substances (TBARS) levels, while also increasing antioxidant markers like glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) in the brain. Additionally, it enhances neuronal organization, increases the proportions of interneurons (SOM+, PV+, CB+), and restores the integrity of the hippocampus. Moreover, RSV modulates epigenetic pathways, such as estrogen receptorbeta (ERβ) activation and sirtuin 1 (Sirt1) expression, counteracts learning, memory, and locomotor activity deficits, and normalizes cortical oscillations. It also potentially modulated gutbrain- axis dysregulation and neurotransmitters.

Conclusion: RSV has shown promising effects on ASD, primarily through its influence on behavioral, neuromolecular, and neurodevelopmental mechanisms.

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摄入白藜芦醇对自闭症谱系障碍神经行为方面的生化影响：系统综述。

简介/目的：自闭症谱系障碍（Autism spectrum disorder， ASD）是以各种神经行为障碍为特征的神经发育障碍。本研究旨在综述白藜芦醇（Resveratrol， RSV）在不同生命阶段对ASD的预防和治疗作用，重点探讨其对行为和神经发育生化机制的影响。方法：于2024年12月6日，对Web of Science、Scopus、PubMed/MEDLINE、Embase、Cochrane Library等几个高覆盖数据库进行全面的电子检索。根据我们的纳入和排除标准筛选出版物后，提取最重要的数据并对其进行审查。结果：RSV通过促进社会互动和减轻重复行为、焦虑和类似抑郁的症状来缓解自闭症样社会行为。RSV影响趋化因子受体表达，降低促炎细胞因子，包括肿瘤坏死因子-α (TNF-α)、白细胞介素-6 （IL-6）和干扰素-γ (IFN-γ)，并通过降低亚硝应激和硫代巴比托酸反应物质（TBARS）水平调节线粒体功能，同时增加抗氧化标志物，如谷胱甘肽（GSH）、过氧化氢酶（CAT）和超氧化物歧化酶（SOD）在大脑中。此外，它还能增强神经元组织，增加中间神经元（SOM+、PV+、CB+）的比例，并恢复海马的完整性。此外，RSV调节表观遗传通路，如雌激素受体β (ERβ)激活和sirtuin 1 （Sirt1）表达，抵消学习、记忆和运动活动缺陷，并使皮质振荡正常化。它还潜在地调节了颅脑轴的失调和神经递质。结论：RSV主要通过影响行为、神经分子和神经发育机制对ASD表现出良好的治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Central nervous system agents in medicinal chemistry

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